DegronMD

Uniprot ID: P41182

Source protein: B-cell lymphoma 6 protein

Source gene: BCL6

Class: LIG_APCC_ABBA_1

Location: 312:317

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9811

ASA_SCORE: 75.3667

COIL: 0.6288

CONS_SCORE: 0.4828

DSS_SCORE: 0.7015

HELIX: 0.261

FCONS_SCORE: 1.1835

RIG_SCORE: 0.7043

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A313T	TCGA-2W-A8YY	CESC	TCGA	IALHFE	LIG_APCC_ABBA_1	0.6028
p.A313T	DO223732	CESC	ICGC	IALHFE	LIG_APCC_ABBA_1	0.6028
p.D310G	TCGA-AP-A056	UCEC	TCGA	IALHFE	LIG_APCC_ABBA_1	0.2778
p.D310G	DO43971	UCEC	ICGC	IALHFE	LIG_APCC_ABBA_1	0.2778
p.E311D	TCGA-AP-A0LM	UCEC	TCGA	IALHFE	LIG_APCC_ABBA_1	0.3056
p.E311D	DO43306	UCEC	ICGC	IALHFE	LIG_APCC_ABBA_1	0.3056
p.E302D	TCGA-BS-A0UJ	UCEC	TCGA	IALHFE	LIG_APCC_ABBA_1	0.0556
p.E302D	DO42745	UCEC	ICGC	IALHFE	LIG_APCC_ABBA_1	0.0556
p.L314V	TCGA-DI-A2QY	UCEC	TCGA	IALHFE	LIG_APCC_ABBA_1	0.5654
p.L314V	DO42031	UCEC	ICGC	IALHFE	LIG_APCC_ABBA_1	0.5654
p.A321T	TCGA-EJ-7783	PRAD	TCGA	IALHFE	LIG_APCC_ABBA_1	0.2222
p.A321T	DO36362	PRAD	ICGC	IALHFE	LIG_APCC_ABBA_1	0.2222
p.A313V	TCGA-FW-A3R5	SKCM	TCGA	IALHFE	LIG_APCC_ABBA_1	0.5825
p.A313V	DO37406	SKCM	ICGC	IALHFE	LIG_APCC_ABBA_1	0.5825
p.K326N	TCGA-UL-AAZ6	BRCA	TCGA	IALHFE	LIG_APCC_ABBA_1	0.1944
p.K326N	DO219644	BRCA	ICGC	IALHFE	LIG_APCC_ABBA_1	0.1944
p.R325W	DO222482	ESCA	ICGC	IALHFE	LIG_APCC_ABBA_1	0.1111
p.A321V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	IALHFE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41182	B-cell lymphoma 6 protein	LIG_APCC_ABBA_1	312:317	IALHFE	APC,CDC20,FZR1	0.9811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons