DegronMD

Uniprot ID: P06733

Source protein: Alpha-enolase

Source gene: ENO1

Class: DEG_ODPH_VHL_1

Location: 73:84

E3 ligase: VHL

DEGRON score: 0.6357

ASA_SCORE: 55.325

COIL: 0.5255

CONS_SCORE: 0.5262

DSS_SCORE: 0.2942

HELIX: 0.4586

FCONS_SCORE: 0.9345

RIG_SCORE: 0.8188

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A74T	TCGA-A5-A0G2	UCEC	TCGA	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.7139
p.A74T	DO41235	UCEC	ICGC	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.7139
p.P75A	TCGA-AD-6965	COAD	TCGA	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.7503
p.P75A	DO9018	COAD	ICGC	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.7503
p.A76T	TCGA-DF-A2KU	UCEC	TCGA	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.6028
p.A76T	DO223286	UCEC	ICGC	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.6028
p.A74V	TCGA-DU-6392	LGG	TCGA	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.6936
p.A74V	TCGA-XK-AAIW	PRAD	TCGA	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.6936
p.A74V	DO22237	LGG	ICGC	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.6936
p.A74V	DO51407	PRAD	ICGC	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.6936
p.A74V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.6936
p.A74V	ACH-001127	Leukemia	CCLE	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.6936
p.A74V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.6936
p.V66I	TCGA-GU-A767	BLCA	TCGA	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.1389
p.V66I	DO51892	BLCA	ICGC	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.1389
p.T85A	TCGA-L5-A43J	ESCA	TCGA	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.3056
p.P75H	TCGA-QK-A6VB	HNSC	TCGA	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.7694
p.P75H	DO219054	HNSC	ICGC	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.7694
p.D91E	DO228986	LICA	ICGC	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.1389
p.S63P	DO229213	THCA	ICGC	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.5
p.K64Q	SIDM00845	Burkitt's Lymphoma	GDSC	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.5278
p.N70S	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.25
p.N70S	ACH-000444	Lung Cancer	CCLE	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.25
p.N70S	LU-99A	lung	COSMIC	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.25
p.N83K	SIDM01582	Gastric Carcinoma	GDSC	IAPALVSKKLNV	DEG_ODPH_VHL_1	0.5806

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06733	Alpha-enolase	DEG_ODPH_VHL_1	73:84	IAPALVSKKLNV	VHL	0.6357	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPALVSKKLNV

Degron related mutations and impact score

Drug responses associated with ENO1 mutations

All proteins holding degron of IAPALVSKKLNV