DegronMD

Uniprot ID: P09769

Source protein: Tyrosine-protein kinase Fgr

Source gene: FGR

Class: DEG_ODPH_VHL_1

Location: 238:251

E3 ligase: VHL

DEGRON score: 0.866

ASA_SCORE: 69.5429

COIL: 0.7236

CONS_SCORE: 0.4767

DSS_SCORE: 0.0825

HELIX: 0.0594

FCONS_SCORE: 0.7435

RIG_SCORE: 0.8873

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R260C	TCGA-A5-A0G2	UCEC	TCGA	IAPCTIMKPQTLGL	DEG_ODPH_VHL_1	0.0833
p.R260C	DO41235	UCEC	ICGC	IAPCTIMKPQTLGL	DEG_ODPH_VHL_1	0.0833
p.P246L	TCGA-A5-A1OF	UCEC	TCGA	IAPCTIMKPQTLGL	DEG_ODPH_VHL_1	0.6471
p.P246L	TCGA-AX-A06H	UCEC	TCGA	IAPCTIMKPQTLGL	DEG_ODPH_VHL_1	0.6471
p.P246L	DO233254	GACA	ICGC	IAPCTIMKPQTLGL	DEG_ODPH_VHL_1	0.6471
p.P246L	DO43530	UCEC	ICGC	IAPCTIMKPQTLGL	DEG_ODPH_VHL_1	0.6471
p.P246L	DO42568	UCEC	ICGC	IAPCTIMKPQTLGL	DEG_ODPH_VHL_1	0.6471
p.S261G	TCGA-AO-A128	BRCA	TCGA	IAPCTIMKPQTLGL	DEG_ODPH_VHL_1	0.5
p.S261G	DO5326	BRCA	ICGC	IAPCTIMKPQTLGL	DEG_ODPH_VHL_1	0.5
p.A255T	TCGA-FI-A2D5	UCEC	TCGA	IAPCTIMKPQTLGL	DEG_ODPH_VHL_1	0.2222
p.A255T	DO41331	UCEC	ICGC	IAPCTIMKPQTLGL	DEG_ODPH_VHL_1	0.2222
p.D231V	SIDM00433	T-Lymphoblastic Leukemia	GDSC	IAPCTIMKPQTLGL	DEG_ODPH_VHL_1	0.1389
p.A239T	ACH-000012	Lung Cancer	CCLE	IAPCTIMKPQTLGL	DEG_ODPH_VHL_1	0.7139
p.A239T	ACH-000029	Lung Cancer	CCLE	IAPCTIMKPQTLGL	DEG_ODPH_VHL_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09769	Tyrosine-protein kinase Fgr	DEG_ODPH_VHL_1	238:251	IAPCTIMKPQTLGL	VHL	0.866	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons