DegronMD

Uniprot ID: Q7Z5Y7

Source protein: BTB/POZ domain-containing protein KCTD20

Source gene: KCTD20

Class: DEG_ODPH_VHL_1

Location: 95:107

E3 ligase: VHL

DEGRON score: 0.5786

ASA_SCORE: 85.5769

COIL: 0.8269

CONS_SCORE: 0.4825

DSS_SCORE: 0.5011

HELIX: 0.0913

FCONS_SCORE: 0.9051

RIG_SCORE: 0.6695

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R89L	TCGA-09-2044	OV	TCGA	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.1667
p.R89L	DO28923	OV	ICGC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.1667
p.N110H	TCGA-AN-A046	BRCA	TCGA	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.25
p.N110H	DO1285	BRCA	ICGC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.25
p.R89W	TCGA-AX-A1C5	UCEC	TCGA	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.1667
p.R89W	TCGA-B5-A3FC	UCEC	TCGA	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.1667
p.R89W	DO41871	UCEC	ICGC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.1667
p.R89W	DO41422	UCEC	ICGC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.1667
p.R89Q	TCGA-AX-A2IN	UCEC	TCGA	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.1667
p.R89Q	DO42328	UCEC	ICGC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.1667
p.A96V	TCGA-EO-A22R	UCEC	TCGA	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.6936
p.A96V	DO42713	UCEC	ICGC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.6936
p.E117D	TCGA-F5-6814	READ	TCGA	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.0556
p.E117D	DO36556	READ	ICGC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.0556
p.N90S	TCGA-G4-6588	COAD	TCGA	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.1944
p.N90S	DO10140	COAD	ICGC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.1944
p.H87Y	DO48438	BLCA	ICGC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.1111
p.H87Y	GEO	large_intestine	COSMIC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.1111
p.G104V	DO229019	LICA	ICGC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.7532
p.G108V	DO229036	LICA	ICGC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.3056
p.Q114R	DO220878	MELA	ICGC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.1389
p.I98V	DO232761	PBCA	ICGC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.7076
p.Q89R	DO42023	UCEC	ICGC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.1667
p.S85N	SIDM00435	Acute Myeloid Leukemia	GDSC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.0556
p.S85N	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.0556
p.S85N	SIDM00242	Osteosarcoma	GDSC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.0556
p.S85N	SIDM00986	Head and Neck Carcinoma	GDSC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.0556
p.S85N	SIDM00026	Other Solid Cancers	GDSC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.0556
p.S85N	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.0556
p.H91Q	SIDM00281	Other Solid Cancers	GDSC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.2222
p.H91Q	SIDM00988	Kidney Carcinoma	GDSC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.2222
p.S85I	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.0556
p.S85I	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.0556
p.I98M	TT2609-C02	thyroid	COSMIC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.7618
p.I101F	NEC8	testis	COSMIC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.7415
p.E116A	KYSE-410	oesophagus	COSMIC	IAPERFGNSSVGF	DEG_ODPH_VHL_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPERFGNSSVGF

Degron related mutations and impact score

Drug responses associated with KCTD20 mutations

All proteins holding degron of IAPERFGNSSVGF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5Y7	BTB/POZ domain-containing protein KCTD20	DEG_ODPH_VHL_1	95:107	IAPERFGNSSVGF	VHL	0.5786	More...