DegronMD

Uniprot ID: O75398

Source protein: Deformed epidermal autoregulatory factor 1 homolog

Source gene: DEAF1

Class: LIG_APCC_ABBA_1

Location: 403:408

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9825

ASA_SCORE: 70.8167

COIL: 0.7302

CONS_SCORE: 0.3312

DSS_SCORE: 0.444

HELIX: 0.1057

FCONS_SCORE: 1.0681

RIG_SCORE: 0.7275

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H393N	TCGA-55-8205	LUAD	TCGA	IAPFPE	LIG_APCC_ABBA_1	0.0556
p.H393N	DO48884	LUAD	ICGC	IAPFPE	LIG_APCC_ABBA_1	0.0556
p.G396C	TCGA-73-4670	LUAD	TCGA	IAPFPE	LIG_APCC_ABBA_1	0.1389
p.G396C	DO25350	LUAD	ICGC	IAPFPE	LIG_APCC_ABBA_1	0.1389
p.P405L	TCGA-B5-A3FC	UCEC	TCGA	IAPFPE	LIG_APCC_ABBA_1	0.6471
p.P405L	DO41871	UCEC	ICGC	IAPFPE	LIG_APCC_ABBA_1	0.6471
p.A410V	DO229053	LICA	ICGC	IAPFPE	LIG_APCC_ABBA_1	0.2778
p.P416L	DO220893	MELA	ICGC	IAPFPE	LIG_APCC_ABBA_1	0.1111
p.P416S	DO220893	MELA	ICGC	IAPFPE	LIG_APCC_ABBA_1	0.1111
p.I403V	SIDM01259	B-Lymphoblastic Leukemia	GDSC	IAPFPE	LIG_APCC_ABBA_1	0.5965
p.I403V	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	IAPFPE	LIG_APCC_ABBA_1	0.5965
p.G396S	SIDM01201	Other Blood Cancers	GDSC	IAPFPE	LIG_APCC_ABBA_1	0.1389
p.P405A	ACH-001430	Bone Cancer	CCLE	IAPFPE	LIG_APCC_ABBA_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75398	Deformed epidermal autoregulatory factor 1 homolog	LIG_APCC_ABBA_1	403:408	IAPFPE	APC,CDC20,FZR1	0.9825	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons