DegronMD

Uniprot ID: Q8NEU8

Source protein: DCC-interacting protein 13-beta

Source gene: APPL2

Class: DEG_ODPH_VHL_1

Location: 444:456

E3 ligase: VHL

DEGRON score: 0.7937

ASA_SCORE: 57.5385

COIL: 0.6745

CONS_SCORE: 0.7105

DSS_SCORE: 0.4255

HELIX: 0.0405

FCONS_SCORE: 1.3007

RIG_SCORE: 0.7987

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E447Q	TCGA-66-2785	LUSC	TCGA	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.6744
p.P455S	TCGA-B5-A3FA	UCEC	TCGA	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.6752
p.D459N	TCGA-EY-A1G8	UCEC	TCGA	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.25
p.S445Y	DO566	BLCA	ICGC	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.712
p.R454W	DO19893	KIRC	ICGC	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.8634
p.R454W	DO222339	STAD	ICGC	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.8634
p.T463K	DO229038	LICA	ICGC	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.1389
p.L456W	DO26461	LUSC	ICGC	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.7015
p.E435Q	DO26790	LUSC	ICGC	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.0833
p.A464P	SIDM00615	Hepatocellular Carcinoma	GDSC	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.1111
p.A464P	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.1111
p.A464P	SIDM01217	Other Blood Cancers	GDSC	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.1111
p.A464P	SIDM00173	Head and Neck Carcinoma	GDSC	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.1111
p.A464P	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.1111
p.A464P	JHH-6	liver	COSMIC	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.1111
p.A464P	KYSE-510	oesophagus	COSMIC	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.1111
p.T448M	ACH-001719	Ovarian Cancer	CCLE	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.6312
p.A458P	KYSE-510	oesophagus	COSMIC	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.2778
p.A458P	JHH-6	liver	COSMIC	IAPGTPIQFDIVL	DEG_ODPH_VHL_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEU8	DCC-interacting protein 13-beta	DEG_ODPH_VHL_1	444:456	IAPGTPIQFDIVL	VHL	0.7937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons