DegronMD

Uniprot ID: Q9NRE2

Source protein: Teashirt homolog 2

Source gene: TSHZ2

Class: DEG_ODPH_VHL_1

Location: 578:590

E3 ligase: VHL

DEGRON score: 0.6527

ASA_SCORE: 102.7462

COIL: 0.9289

CONS_SCORE: 0.4475

DSS_SCORE: 0.3397

HELIX: 0.0382

FCONS_SCORE: 1.0097

RIG_SCORE: 0.7869

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P586S	TCGA-19-5956	GBM	TCGA	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.5641
p.P580T	TCGA-33-AASD	LUSC	TCGA	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.7031
p.A595S	TCGA-44-6774	LUAD	TCGA	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.1944
p.P577H	TCGA-97-A4M7	LUAD	TCGA	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.3056
p.S589Y	TCGA-CA-6717	COAD	TCGA	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.6009
p.V588I	TCGA-D3-A8GO	SKCM	TCGA	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.5965
p.R568Q	TCGA-E2-A14Y	BRCA	TCGA	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.0556
p.K581M	TCGA-R6-A6XQ	ESCA	TCGA	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.6951
p.S586Y	DO8264	COAD	ICGC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.712
p.P583S	DO13863	GBM	ICGC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.6752
p.P574H	DO45386	LUAD	ICGC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.3333
p.A592S	DO25000	LUAD	ICGC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.2778
p.K598N	DO26469	LUSC	ICGC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.1111
p.K598N	DO49478	PACA	ICGC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.1111
p.P577T	DO219127	LUSC	ICGC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.3056
p.L568F	DO229470	SKCA	ICGC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.0556
p.P577L	DO229502	SKCA	ICGC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.3056
p.V585I	DO51242	SKCM	ICGC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.7076
p.T572A	SIDM00672	Hepatocellular Carcinoma	GDSC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.1667
p.T572A	SIDM01504	Small Cell Lung Carcinoma	GDSC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.1667
p.K581Q	SIDM00042	Pancreatic Carcinoma	GDSC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.5833
p.K581Q	ACH-002186	Pancreatic Cancer	CCLE	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.5833
p.K581Q	PL4	pancreas	COSMIC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.5833
p.T572S	SIDM00928	Breast Carcinoma	GDSC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.1667
p.T572S	CAL-85-1	breast	COSMIC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.1667
p.H593Q	SIDM01182	Bladder Carcinoma	GDSC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.25
p.H593Q	UM-UC-3	urinary_tract	COSMIC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.25
p.P577S	SIDM00980	Gastric Carcinoma	GDSC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.3056
p.P577S	ACH-000948	Gastric Cancer	CCLE	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.3056
p.P577S	23132-87	stomach	COSMIC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.3056
p.A595V	SIDM01746	Osteosarcoma	GDSC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.1944
p.P574S	23132-87	stomach	COSMIC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.3333
p.K578Q	PL4	pancreas	COSMIC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.6944
p.H590Q	UM-UC-3	urinary_tract	COSMIC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.7582
p.T569S	CAL-85-1	breast	COSMIC	IAPKWKVMPLVSM	DEG_ODPH_VHL_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPKWKVMPLVSM

Degron related mutations and impact score

Drug responses associated with TSHZ2 mutations

All proteins holding degron of IAPKWKVMPLVSM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRE2	Teashirt homolog 2	DEG_ODPH_VHL_1	578:590	IAPKWKVMPLVSM	VHL	0.6527	More...