DegronMD

Uniprot ID: Q9NZI8

Source protein: Insulin-like growth factor 2 mRNA-binding protein 1

Source gene: IGF2BP1

Class: DEG_ODPH_VHL_1

Location: 441:453

E3 ligase: VHL

DEGRON score: 0.997

ASA_SCORE: 75.0462

COIL: 0.7958

CONS_SCORE: 0.4526

DSS_SCORE: 0.4393

HELIX: 0.0486

FCONS_SCORE: 0.8593

RIG_SCORE: 0.7224

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K440N	TCGA-Q1-A5R2	CESC	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.75
p.K440N	DO49003	CESC	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.75
p.R452C	TCGA-06-5416	GBM	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	TCGA-19-5956	GBM	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	TCGA-AP-A0LM	UCEC	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	TCGA-B5-A0JY	UCEC	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	TCGA-EE-A2MR	SKCM	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	TCGA-FR-A7U9	SKCM	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	TCGA-WE-A8ZO	SKCM	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO13863	GBM	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO10880	GBM	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO220886	MELA	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO48546	SKCM	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO37819	SKCM	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO51286	SKCM	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO43306	UCEC	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO43041	UCEC	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452H	SIDM01619	Endometrial Carcinoma	GDSC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.7133
p.R452H	ACH-000984	Endometrial/Uterine Cancer	CCLE	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.7133
p.A442V	TCGA-DU-6408	LGG	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.6936
p.A442V	DO22245	LGG	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.6936
p.R452G	TCGA-38-4629	LUAD	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.6457
p.R452G	DO23771	LUAD	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.6457
p.S449Y	TCGA-17-Z030	LUAD	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.6009
p.E445K	DO33344	PACA	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.591

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Drug responses associated with IGF2BP1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of IAPPETPDSKVRM

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZI8	Insulin-like growth factor 2 mRNA-binding protein 1	DEG_ODPH_VHL_1	441:453	IAPPETPDSKVRM	VHL	0.997	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPPETPDSKVRM

Degron related mutations and impact score

Drug responses associated with IGF2BP1 mutations

All proteins holding degron of IAPPETPDSKVRM