DegronMD

Uniprot ID: Q9NZI8

Source protein: Insulin-like growth factor 2 mRNA-binding protein 1

Source gene: IGF2BP1

Class: DEG_ODPH_VHL_1

Location: 441:453

E3 ligase: VHL

DEGRON score: 0.997

ASA_SCORE: 75.0462

COIL: 0.7958

CONS_SCORE: 0.4526

DSS_SCORE: 0.4393

HELIX: 0.0486

FCONS_SCORE: 0.8593

RIG_SCORE: 0.7224

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R452C	TCGA-06-5416	GBM	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	TCGA-19-5956	GBM	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	TCGA-AP-A0LM	UCEC	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	TCGA-B5-A0JY	UCEC	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	TCGA-EE-A2MR	SKCM	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	TCGA-FR-A7U9	SKCM	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	TCGA-WE-A8ZO	SKCM	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO13863	GBM	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO10880	GBM	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO220886	MELA	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO48546	SKCM	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO37819	SKCM	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO51286	SKCM	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO43306	UCEC	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.R452C	DO43041	UCEC	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.719
p.V454F	TCGA-12-1088	GBM	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.3056
p.V454F	DO13701	GBM	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.3056
p.S449Y	TCGA-17-Z030	LUAD	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.6009
p.R452G	TCGA-38-4629	LUAD	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.6457
p.R452G	DO23771	LUAD	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.6457
p.A442V	TCGA-DU-6408	LGG	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.6936
p.A442V	DO22245	LGG	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.6936
p.K440N	TCGA-Q1-A5R2	CESC	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.75
p.K440N	DO49003	CESC	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.75
p.P460S	TCGA-RP-A695	SKCM	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.1389
p.P460S	DO51270	SKCM	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.1389
p.E461K	TCGA-VS-A9UP	CESC	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.1111
p.E461K	DO219737	CESC	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.1111
p.P459L	TCGA-Z2-AA3S	SKCM	TCGA	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.1667
p.P459L	DO51302	SKCM	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.1667
p.G458V	DO228896	LICA	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.1944
p.G458V	DO229019	LICA	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.1944
p.R433L	DO228986	LICA	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.1111
p.R433L	SIDM00216	Colorectal Carcinoma	GDSC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.1111
p.R433L	ACH-000989	Colon/Colorectal Cancer	CCLE	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.1111
p.R433L	SNU-175	large_intestine	COSMIC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.1111
p.E445K	DO33344	PACA	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.591
p.E445K	ACH-000455	Brain Cancer	CCLE	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.591
p.R433Q	DO229548	PRAD	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.1111
p.A437T	DO41199	UCEC	ICGC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.2222
p.R452H	SIDM01619	Endometrial Carcinoma	GDSC	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.7133
p.R452H	ACH-000984	Endometrial/Uterine Cancer	CCLE	IAPPETPDSKVRM	DEG_ODPH_VHL_1	0.7133

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPPETPDSKVRM

Degron related mutations and impact score

Drug responses associated with IGF2BP1 mutations

All proteins holding degron of IAPPETPDSKVRM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZI8	Insulin-like growth factor 2 mRNA-binding protein 1	DEG_ODPH_VHL_1	441:453	IAPPETPDSKVRM	VHL	0.997	More...