DegronMD

Uniprot ID: P19419

Source protein: ETS domain-containing protein Elk-1

Source gene: ELK1

Class: DEG_ODPH_VHL_1

Location: 385:397

E3 ligase: VHL

DEGRON score: 0.9976

ASA_SCORE: 72.4462

COIL: 0.7463

CONS_SCORE: 0.6032

DSS_SCORE: 0.3064

HELIX: 0.1192

FCONS_SCORE: 0.9926

RIG_SCORE: 0.7154

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R388C	TCGA-17-Z017	LUAD	TCGA	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.719
p.S402N	TCGA-19-5951	GBM	TCGA	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.1944
p.S402N	DO14067	GBM	ICGC	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.1944
p.W379C	TCGA-3X-AAV9	CHOL	TCGA	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.1667
p.F397S	TCGA-AJ-A3EL	UCEC	TCGA	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.7982
p.F397S	DO41542	UCEC	ICGC	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.7982
p.F378L	TCGA-D1-A17Q	UCEC	TCGA	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.1389
p.F378L	DO41903	UCEC	ICGC	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.1389
p.A391D	TCGA-DU-6392	LGG	TCGA	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.6682
p.A391D	DO22237	LGG	ICGC	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.6682
p.S383T	TCGA-F4-6703	COAD	TCGA	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.7222
p.P390L	DO233882	GACA	ICGC	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.6471
p.S380R	DO229019	LICA	ICGC	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.1944
p.H377N	DO229019	LICA	ICGC	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.1111
p.R388H	DO48682	LIRI	ICGC	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.7133
p.S394P	ACH-000823	Esophageal Cancer	CCLE	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.5641
p.S394P	KYSE-140	oesophagus	COSMIC	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.5641
p.A386V	ACH-002023	Colon/Colorectal Cancer	CCLE	IAPRSPAKLSFQF	DEG_ODPH_VHL_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19419	ETS domain-containing protein Elk-1	DEG_ODPH_VHL_1	385:397	IAPRSPAKLSFQF	VHL	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons