DegronMD

Uniprot ID: P49959

Source protein: Double-strand break repair protein MRE11

Source gene: MRE11

Class: DEG_ODPH_VHL_1

Location: 251:263

E3 ligase: VHL

DEGRON score: 0.5999

ASA_SCORE: 67.6538

COIL: 0.53

CONS_SCORE: 0.3968

DSS_SCORE: 0.2925

HELIX: 0.0407

FCONS_SCORE: 0.5269

RIG_SCORE: 0.8247

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E248K	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	IAPTKNEQQLFYI	DEG_ODPH_VHL_1	0.25
p.E248K	NCI-H441	lung	COSMIC	IAPTKNEQQLFYI	DEG_ODPH_VHL_1	0.25
p.E251K	NCI-H441	lung	COSMIC	IAPTKNEQQLFYI	DEG_ODPH_VHL_1	0.7022

Drug responses associated with MRE11 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00678	BLCA\|bladder	p.S613L (No)	GDSC	Mirin	869.8893
SIDM00678	BLCA\|bladder	p.S613L (No)	GDSC	Mirin	6648.9
SIDM00772	BRCA\|breast	p.H302Y (No)	GDSC	Mirin	168.0188
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.G182* (No)	GDSC	Mirin	206.2222
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.L181F (No)	GDSC	Mirin	206.2222
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R305W (No)	GDSC	Mirin	34.0478
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R305W (No)	GDSC	Mirin	83.663
SIDM00151	OV\|ovary	p.R525K (No)	GDSC	Mirin	557.8544
SIDM00151	OV\|ovary	p.R525K (No)	GDSC	Mirin	39.094
SIDM00151	OV\|ovary	p.A440T (No)	GDSC	Mirin	557.8544
SIDM00151	OV\|ovary	p.A440T (No)	GDSC	Mirin	39.094
SIDM00208	LGG\|glioma	p.R351H (No)	GDSC	Mirin	509.8166
SIDM00957	COREAD\|large_intestine	p.A47S (No)	GDSC	Mirin	216.4155
SIDM00957	COREAD\|large_intestine	p.A47S (No)	GDSC	Mirin	2063.2
SIDM00519	MESO\|mesothelioma	p.D131Y (No)	GDSC	Mirin	264.9841
SIDM00519	MESO\|mesothelioma	p.D131Y (No)	GDSC	Mirin	925.42
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A551T (No)	GDSC	Mirin	33.7344
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A551T (No)	GDSC	Mirin	45.798
SIDM00142	UCEC\|endometrium	p.Q330K (No)	GDSC	Mirin	20.2329
SIDM00142	UCEC\|endometrium	p.Q330K (No)	GDSC	Mirin	51.067
SIDM01190	BLCA\|bladder	p.E471Q (No)	GDSC	Mirin	189.5955
SIDM01190	BLCA\|bladder	p.E471Q (No)	GDSC	Mirin	1121.3
SIDM00980	STAD\|stomach	p.P358Q (No)	GDSC	Mirin	32.9256
SIDM00980	STAD\|stomach	p.P358Q (No)	GDSC	Mirin	25.086
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.G285C (No)	GDSC	Mirin	98.1851
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.G285C (No)	GDSC	Mirin	294.13
SIDM00041	UNCLASSIFIED\|soft_tissue_other	p.R388W (No)	GDSC	Mirin	299.9033
SIDM00516	SKCM\|melanoma	p.G589E (No)	GDSC	Mirin	53.1823
SIDM00564	OV\|ovary	p.L61F (No)	GDSC	Mirin	1028.0766
SIDM00564	OV\|ovary	p.L61F (No)	GDSC	Mirin	164.67
SIDM00373	UCEC\|endometrium	p.N511fs*13 (No)	GDSC	Mirin	149.449
SIDM00373	UCEC\|endometrium	p.N511fs*13 (No)	GDSC	Mirin	115.42
SIDM00946	ALL\|T_cell_leukemia	p.R400S (No)	GDSC	Mirin	64.3322
SIDM00946	ALL\|T_cell_leukemia	p.R400S (No)	GDSC	Mirin	74.854
SIDM00333	UCEC\|endometrium	p.V17I (No)	GDSC	Mirin	246.7886
SIDM00333	UCEC\|endometrium	p.V17I (No)	GDSC	Mirin	118.51
SIDM01155	GBM\|glioma	p.E552K (No)	GDSC	Mirin	1140.6437
SIDM01155	GBM\|glioma	p.E552K (No)	GDSC	Mirin	625.39
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.D468H (No)	GDSC	Mirin	333.198
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.D468H (No)	GDSC	Mirin	206.77
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.L169P (No)	GDSC	Mirin	333.198
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.L169P (No)	GDSC	Mirin	206.77
SIDM00999	BLCA\|bladder	p.R572Q (No)	GDSC	Mirin	61.7935
SIDM00999	BLCA\|bladder	p.R572Q (No)	GDSC	Mirin	62.034
SIDM00217	COREAD\|large_intestine	p.S547G (No)	GDSC	Mirin	871.7023
SIDM00217	COREAD\|large_intestine	p.S547G (No)	GDSC	Mirin	410.63
SIDM00217	COREAD\|large_intestine	p.R349Q (No)	GDSC	Mirin	871.7023
SIDM00217	COREAD\|large_intestine	p.R349Q (No)	GDSC	Mirin	410.63
SIDM00596	UCEC\|endometrium	p.T36M (No)	GDSC	Mirin	66.9084
SIDM00596	UCEC\|endometrium	p.T36M (No)	GDSC	Mirin	450.18
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.E248K (Yes)	GDSC	Mirin	170.766
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.E248K (Yes)	GDSC	Mirin	6856.8
SIDM00660	COREAD\|large_intestine	p.F399fs*29 (No)	GDSC	Mirin	47.5947
SIDM00660	COREAD\|large_intestine	p.F399fs*29 (No)	GDSC	Mirin	70.258
SIDM00832	COREAD\|large_intestine	p.R380C (No)	GDSC	Mirin	3033.684
SIDM00832	COREAD\|large_intestine	p.R380C (No)	GDSC	Mirin	308.96
SIDM00359	COREAD\|large_intestine	p.R488H (No)	GDSC	Mirin	74.8602
SIDM00359	COREAD\|large_intestine	p.R488H (No)	GDSC	Mirin	166.33
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.Q48L (No)	GDSC	Mirin	179.4199
SIDM00737	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G593E (No)	GDSC	Mirin	403.9189
SIDM00737	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G593R (No)	GDSC	Mirin	403.9189
SIDM00607	LGG\|glioma	p.R191fs*5 (No)	GDSC	Mirin	128.0468
SIDM00680	COREAD\|large_intestine	p.T481fs*43 (No)	GDSC	Mirin	237.5901
SIDM00680	COREAD\|large_intestine	p.T481fs*43 (No)	GDSC	Mirin	48.453
SIDM00207	GBM\|glioma	p.V444M (No)	GDSC	Mirin	173.3071
SIDM00493	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.D86N (No)	GDSC	Mirin	27.0959
SIDM00343	GBM\|glioma	p.Q232K (No)	GDSC	Mirin	846.1046
SIDM00343	GBM\|glioma	p.Q232K (No)	GDSC	Mirin	799.94
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L473S (No)	GDSC	Mirin	273.4684
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L473S (No)	GDSC	Mirin	87.183
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.G114fs*31 (No)	GDSC	Mirin	2043.9878
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.G114fs*31 (No)	GDSC	Mirin	193.08
SIDM01259	ALL\|lymphoblastic_leukemia	p.A564T (No)	GDSC	Mirin	47.3682
SIDM01259	ALL\|lymphoblastic_leukemia	p.A564T (No)	GDSC	Mirin	92.752
SIDM00238	OV\|ovary	p.R87W (No)	GDSC	Mirin	138.3756
SIDM00238	OV\|ovary	p.R87W (No)	GDSC	Mirin	91.682
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S209F (No)	GDSC	Mirin	1340.4183
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S209F (No)	GDSC	Mirin	98.096
SIDM00193	COREAD\|large_intestine	p.E494K (No)	GDSC	Mirin	71.289
SIDM00193	COREAD\|large_intestine	p.E494K (No)	GDSC	Mirin	138.22
SIDM00193	COREAD\|large_intestine	p.R483L (No)	GDSC	Mirin	71.289
SIDM00193	COREAD\|large_intestine	p.R483L (No)	GDSC	Mirin	138.22
SIDM00193	COREAD\|large_intestine	p.R80I (No)	GDSC	Mirin	71.289
SIDM00193	COREAD\|large_intestine	p.R80I (No)	GDSC	Mirin	138.22

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPTKNEQQLFYI

Degron related mutations and impact score

Drug responses associated with MRE11 mutations

All proteins holding degron of IAPTKNEQQLFYI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49959	Double-strand break repair protein MRE11	DEG_ODPH_VHL_1	251:263	IAPTKNEQQLFYI	VHL	0.5999	More...