DegronMD

Uniprot ID: Q14164

Source protein: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Source gene: IKBKE

Class: DEG_ODPH_VHL_1

Location: 668:681

E3 ligase: VHL

DEGRON score: 0.8008

ASA_SCORE: 87.7214

COIL: 0.5589

CONS_SCORE: 0.3602

DSS_SCORE: 0.5199

HELIX: 0.4307

FCONS_SCORE: 0.8534

RIG_SCORE: 0.6947

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y671S	TCGA-73-4666	LUAD	TCGA	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.712
p.Y671S	DO26230	LUAD	ICGC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.712
p.P665T	TCGA-86-A4JF	LUAD	TCGA	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.25
p.P665T	DO45317	LUAD	ICGC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.25
p.P665S	TCGA-AP-A0LM	UCEC	TCGA	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.25
p.P665S	DO43306	UCEC	ICGC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.25
p.G689W	TCGA-D3-A3C8	SKCM	TCGA	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1111
p.G689W	DO47636	SKCM	ICGC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1111
p.P672H	TCGA-EE-A20F	SKCM	TCGA	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.6583
p.P672H	DO37961	SKCM	ICGC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.6583
p.A661V	TCGA-EO-A22U	UCEC	TCGA	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1389
p.A661V	DO43755	UCEC	ICGC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1389
p.L681F	TCGA-ER-A19N	SKCM	TCGA	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.587
p.L681F	DO37452	SKCM	ICGC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.587
p.D678Y	DO229022	LICA	ICGC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.6214
p.R676Q	DO222494	MELA	ICGC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.6218
p.A661D	DO232761	PBCA	ICGC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1389
p.P665L	SIDM00958	Chronic Myelogenous Leukemia	GDSC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.25
p.P665L	ACH-000920	Leukemia	CCLE	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.25
p.G660E	SIDM00584	Osteosarcoma	GDSC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1111
p.G660E	SIDM00394	Cervical Carcinoma	GDSC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1111
p.G660E	SIDM01653	Non-Cancerous	GDSC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1111
p.G660E	SIDM00207	Glioblastoma	GDSC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1111
p.G660E	SIDM00018	Acute Myeloid Leukemia	GDSC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1111
p.G660E	SIDM01582	Gastric Carcinoma	GDSC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1111
p.G660E	SIDM01444	Glioblastoma	GDSC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1111
p.G660E	SIDM01343	Gastric Carcinoma	GDSC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1111
p.G660E	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1111
p.G660E	KO52	haematopoietic_and_lymphoid_tissue	COSMIC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1111
p.G660E	SISO	cervix	COSMIC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1111
p.G660E	HuO-3N1	bone	COSMIC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1111
p.A663V	SIDM01259	B-Lymphoblastic Leukemia	GDSC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1944
p.A663V	ACH-001669	Leukemia	CCLE	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1944
p.A663V	ACH-002238	Leukemia	CCLE	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1944
p.A663V	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1944
p.E688K	SIDM01001	Breast Carcinoma	GDSC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1389
p.E688K	ACH-000258	Breast Cancer	CCLE	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1389
p.E688K	DU-4475	breast	COSMIC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.1389
p.S664L	SIDM01511	Gastric Carcinoma	GDSC	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.6667
p.S664L	ACH-000746	Gastric Cancer	CCLE	IAPYPSPTRKDLLL	DEG_ODPH_VHL_1	0.6667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPYPSPTRKDLLL

Degron related mutations and impact score

Drug responses associated with IKBKE mutations

All proteins holding degron of IAPYPSPTRKDLLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14164	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	DEG_ODPH_VHL_1	668:681	IAPYPSPTRKDLLL	VHL	0.8008	More...