DegronMD

Uniprot ID: Q6V9R5

Source protein: Zinc finger protein 562

Source gene: ZNF562

Class: LIG_APCC_ABBA_1

Location: 16:21

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9907

ASA_SCORE: 72.25

COIL: 0.6988

CONS_SCORE: 0.1647

DSS_SCORE: 0.3876

HELIX: 0.2622

FCONS_SCORE: 1.1166

RIG_SCORE: 0.7884

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F11L	TCGA-A6-5665	COAD	TCGA	ICPFEE	LIG_APCC_ABBA_1	0.1944
p.F11L	DO9756	COAD	ICGC	ICPFEE	LIG_APCC_ABBA_1	0.1944
p.T27M	TCGA-AA-3811	COAD	TCGA	ICPFEE	LIG_APCC_ABBA_1	0.1667
p.T27M	DO7962	COAD	ICGC	ICPFEE	LIG_APCC_ABBA_1	0.1667
p.T27M	DO227549	COCA	ICGC	ICPFEE	LIG_APCC_ABBA_1	0.1667
p.R13M	TCGA-EA-A410	CESC	TCGA	ICPFEE	LIG_APCC_ABBA_1	0.25
p.R13M	DO49929	CESC	ICGC	ICPFEE	LIG_APCC_ABBA_1	0.25
p.M6V	TCGA-VR-A8EO	ESCA	TCGA	ICPFEE	LIG_APCC_ABBA_1	0.0556
p.E17K	DO516	BLCA	ICGC	ICPFEE	LIG_APCC_ABBA_1	0.7022
p.I16M	DO233797	GACA	ICGC	ICPFEE	LIG_APCC_ABBA_1	0.6507
p.L29I	DO228948	LICA	ICGC	ICPFEE	LIG_APCC_ABBA_1	0.1111
p.P22T	DO229025	LICA	ICGC	ICPFEE	LIG_APCC_ABBA_1	0.75
p.T23K	DO222696	MELA	ICGC	ICPFEE	LIG_APCC_ABBA_1	0.2778
p.S28T	DO229268	THCA	ICGC	ICPFEE	LIG_APCC_ABBA_1	0.1389
p.F12I	M14	skin	COSMIC	ICPFEE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6V9R5	Zinc finger protein 562	LIG_APCC_ABBA_1	16:21	ICPFEE	APC,CDC20,FZR1	0.9907	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons