DegronMD

Uniprot ID: O00159

Source protein: Unconventional myosin-Ic

Source gene: MYO1C

Class: DEG_SCF_FBW7_2

Location: 1035:1042

E3 ligase: FBXW7

DEGRON score: 0.9811

ASA_SCORE: 55.9

COIL: 0.5296

CONS_SCORE: 0.6058

DSS_SCORE: 0.4173

HELIX: 0.0149

FCONS_SCORE: 1.0593

RIG_SCORE: 0.778

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1028A	TCGA-3B-A9HT	SARC	TCGA	IDFTPGSE	DEG_SCF_FBW7_2	0.1389
p.D1036N	TCGA-50-5939	LUAD	TCGA	IDFTPGSE	DEG_SCF_FBW7_2	0.5821
p.S1041P	TCGA-D5-6534	COAD	TCGA	IDFTPGSE	DEG_SCF_FBW7_2	0.6752
p.R1031S	TCGA-EY-A215	UCEC	TCGA	IDFTPGSE	DEG_SCF_FBW7_2	0.2222
p.P1029S	TCGA-FR-A3R1	SKCM	TCGA	IDFTPGSE	DEG_SCF_FBW7_2	0.1667
p.P1039R	TCGA-VS-A9U6	CESC	TCGA	IDFTPGSE	DEG_SCF_FBW7_2	0.7512
p.R1044L	DO7918	COAD	ICGC	IDFTPGSE	DEG_SCF_FBW7_2	0.2778
p.S1043F	DO223286	UCEC	ICGC	IDFTPGSE	DEG_SCF_FBW7_2	0.3056
p.A1026G	SIDM00951	T-Lymphoblastic Leukemia	GDSC	IDFTPGSE	DEG_SCF_FBW7_2	0.0833
p.A1026G	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	IDFTPGSE	DEG_SCF_FBW7_2	0.0833
p.I1045T	CP67-MEL	skin	COSMIC	IDFTPGSE	DEG_SCF_FBW7_2	0.25
p.I1026T	CP67-MEL	skin	COSMIC	IDFTPGSE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00159	Unconventional myosin-Ic	DEG_SCF_FBW7_2	1035:1042	IDFTPGSE	FBXW7	0.9811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons