DegronMD

Uniprot ID: Q9UPV0

Source protein: Centrosomal protein of 164 kDa

Source gene: CEP164

Class: DEG_SCF_FBW7_1

Location: 1250:1257

E3 ligase: FBXW7

DEGRON score: 0.9919

ASA_SCORE: 80.95

COIL: 0.8859

CONS_SCORE: 0.6722

DSS_SCORE: 0.4412

HELIX: 0.0936

FCONS_SCORE: 0.9742

RIG_SCORE: 0.6891

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1249G	TCGA-DV-A4W0	KIRC	TCGA	IDSTPSLT	DEG_SCF_FBW7_1	0.3056
p.R1249G	DO219235	KIRC	ICGC	IDSTPSLT	DEG_SCF_FBW7_1	0.3056
p.H1262Y	TCGA-EE-A29D	SKCM	TCGA	IDSTPSLT	DEG_SCF_FBW7_1	0.1944
p.H1262Y	DO38123	SKCM	ICGC	IDSTPSLT	DEG_SCF_FBW7_1	0.1944
p.R1259H	TCGA-F7-A624	HNSC	TCGA	IDSTPSLT	DEG_SCF_FBW7_1	0.2778
p.R1259H	DO44440	HNSC	ICGC	IDSTPSLT	DEG_SCF_FBW7_1	0.2778
p.R1242H	DO222501	COCA	ICGC	IDSTPSLT	DEG_SCF_FBW7_1	0.1111
p.W1244C	DO228976	LICA	ICGC	IDSTPSLT	DEG_SCF_FBW7_1	0.1667
p.I1261F	DO50886	LICA	ICGC	IDSTPSLT	DEG_SCF_FBW7_1	0.2222
p.P1254L	DO228424	MALY	ICGC	IDSTPSLT	DEG_SCF_FBW7_1	0.7582
p.S1267F	DO222644	MELA	ICGC	IDSTPSLT	DEG_SCF_FBW7_1	0.5
p.R1242C	SIDM02040	Esophageal Carcinoma	GDSC	IDSTPSLT	DEG_SCF_FBW7_1	0.1111
p.S1258F	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	IDSTPSLT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SCF_FBW7_1	1250:1257	IDSTPSLT	FBXW7	0.9919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons