DegronMD

Uniprot ID: Q86WG3

Source protein: Caytaxin

Source gene: ATCAY

Class: DEG_SCF_FBW7_1

Location: 98:104

E3 ligase: FBXW7

DEGRON score: 0.9917

ASA_SCORE: 86.6286

COIL: 0.8389

CONS_SCORE: 0.6543

DSS_SCORE: 0.5976

HELIX: 0.1314

FCONS_SCORE: 0.9976

RIG_SCORE: 0.7749

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D105N	TCGA-AG-3591	READ	TCGA	IETPDET	DEG_SCF_FBW7_1	0.3056
p.D90Y	TCGA-AG-A002	READ	TCGA	IETPDET	DEG_SCF_FBW7_1	0.1111
p.N114K	TCGA-D9-A4Z3	SKCM	TCGA	IETPDET	DEG_SCF_FBW7_1	0.0556
p.D92N	TCGA-EE-A29E	SKCM	TCGA	IETPDET	DEG_SCF_FBW7_1	0.1667
p.D92N	DO219501	SKCM	ICGC	IETPDET	DEG_SCF_FBW7_1	0.1667
p.E99K	TCGA-F4-6703	COAD	TCGA	IETPDET	DEG_SCF_FBW7_1	0.591
p.E99K	TCGA-ND-A4WC	UCS	TCGA	IETPDET	DEG_SCF_FBW7_1	0.591
p.E99D	TCGA-FI-A2D5	UCEC	TCGA	IETPDET	DEG_SCF_FBW7_1	0.5647
p.E108K	TCGA-FR-A7U9	SKCM	TCGA	IETPDET	DEG_SCF_FBW7_1	0.2222
p.G111E	TCGA-W3-AA21	SKCM	TCGA	IETPDET	DEG_SCF_FBW7_1	0.1389
p.T106N	DO223376	CLLE	ICGC	IETPDET	DEG_SCF_FBW7_1	0.2778
p.E105K	DO9908	COAD	ICGC	IETPDET	DEG_SCF_FBW7_1	0.3056
p.T106I	DO10859	ESAD	ICGC	IETPDET	DEG_SCF_FBW7_1	0.2778
p.L113Q	DO231954	LICA	ICGC	IETPDET	DEG_SCF_FBW7_1	0.0833
p.L91F	DO228974	LICA	ICGC	IETPDET	DEG_SCF_FBW7_1	0.1389
p.D98Y	DO228974	LICA	ICGC	IETPDET	DEG_SCF_FBW7_1	0.7325
p.D111N	DO37316	READ	ICGC	IETPDET	DEG_SCF_FBW7_1	0.1389
p.E114K	DO48546	SKCM	ICGC	IETPDET	DEG_SCF_FBW7_1	0.0556
p.D98N	DO37831	SKCM	ICGC	IETPDET	DEG_SCF_FBW7_1	0.6932
p.E105D	DO41331	UCEC	ICGC	IETPDET	DEG_SCF_FBW7_1	0.3056
p.T100A	SIDM00216	Colorectal Carcinoma	GDSC	IETPDET	DEG_SCF_FBW7_1	0.7139
p.T100A	ACH-000989	Colon/Colorectal Cancer	CCLE	IETPDET	DEG_SCF_FBW7_1	0.7139
p.T100A	SNU-175	large_intestine	COSMIC	IETPDET	DEG_SCF_FBW7_1	0.7139
p.D102N	SIDM01611	Endometrial Carcinoma	GDSC	IETPDET	DEG_SCF_FBW7_1	0.5821
p.D102N	ACH-000996	Endometrial/Uterine Cancer	CCLE	IETPDET	DEG_SCF_FBW7_1	0.5821
p.D102A	SIDM01611	Endometrial Carcinoma	GDSC	IETPDET	DEG_SCF_FBW7_1	0.6682
p.D102A	ACH-000996	Endometrial/Uterine Cancer	CCLE	IETPDET	DEG_SCF_FBW7_1	0.6682

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WG3	Caytaxin	DEG_SCF_FBW7_1	98:104	IETPDET	FBXW7	0.9917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IETPDET

Degron related mutations and impact score

Drug responses associated with ATCAY mutations

All proteins holding degron of IETPDET