DegronMD

Uniprot ID: Q9Y4C8

Source protein: Probable RNA-binding protein 19

Source gene: RBM19

Class: LIG_APCC_ABBA_1

Location: 362:367

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8497

ASA_SCORE: 52.2167

COIL: 0.185

CONS_SCORE: 0.254

DSS_SCORE: 0.3618

HELIX: 0.0177

FCONS_SCORE: 1.0858

RIG_SCORE: 0.8736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N353D	TCGA-66-2767	LUSC	TCGA	IEVFRE	LIG_APCC_ABBA_1	0.0833
p.N353D	DO26713	LUSC	ICGC	IEVFRE	LIG_APCC_ABBA_1	0.0833
p.V364M	TCGA-DA-A1HV	SKCM	TCGA	IEVFRE	LIG_APCC_ABBA_1	0.6097
p.V364M	DO37659	SKCM	ICGC	IEVFRE	LIG_APCC_ABBA_1	0.6097
p.N353S	TCGA-DI-A1BU	UCEC	TCGA	IEVFRE	LIG_APCC_ABBA_1	0.0833
p.N353S	DO42023	UCEC	ICGC	IEVFRE	LIG_APCC_ABBA_1	0.0833
p.R360C	TCGA-EO-A22U	UCEC	TCGA	IEVFRE	LIG_APCC_ABBA_1	0.2778
p.R360C	DO43755	UCEC	ICGC	IEVFRE	LIG_APCC_ABBA_1	0.2778
p.E355K	DO50314	ESAD	ICGC	IEVFRE	LIG_APCC_ABBA_1	0.1389
p.E355K	DO48205	ESCA	ICGC	IEVFRE	LIG_APCC_ABBA_1	0.1389
p.N369K	DO229029	LICA	ICGC	IEVFRE	LIG_APCC_ABBA_1	0.2778
p.R360S	DO229029	LICA	ICGC	IEVFRE	LIG_APCC_ABBA_1	0.2778
p.R360L	DO50684	ORCA	ICGC	IEVFRE	LIG_APCC_ABBA_1	0.2778
p.M357I	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	IEVFRE	LIG_APCC_ABBA_1	0.1944
p.M357I	SIDM00162	Biliary Tract Carcinoma	GDSC	IEVFRE	LIG_APCC_ABBA_1	0.1944
p.M357I	RERF-LC-Sq1	lung	COSMIC	IEVFRE	LIG_APCC_ABBA_1	0.1944
p.R354W	WM-115	skin	COSMIC	IEVFRE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4C8	Probable RNA-binding protein 19	LIG_APCC_ABBA_1	362:367	IEVFRE	APC,CDC20,FZR1	0.8497	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons