DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
IFTPAHE
Uniprot ID:
C9JLW8
Source protein:
Mapk-regulated corepressor-interacting protein 1
Source gene:
MCRIP1
Class:
DEG_SCF_FBW7_2
Location:
28:34
E3 ligase:
FBXW7
DEGRON score:
0.9916
ASA_SCORE:
69.2286
COIL:
0.5501
CONS_SCORE:
0.9549
DSS_SCORE:
0.4542
HELIX:
0.4159
FCONS_SCORE:
1.1708
RIG_SCORE:
0.7213
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MCRIP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IFTPAHE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
C9JLW8
Mapk-regulated corepressor-interacting protein 1
DEG_SCF_FBW7_2
28:34
IFTPAHE
FBXW7
0.9916
More...