DegronMD

Uniprot ID: O15393

Source protein: Transmembrane protease serine 2

Source gene: TMPRSS2

Class: LIG_APCC_ABBA_1

Location: 11:16

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8787

ASA_SCORE: 69.0167

COIL: 0.8423

CONS_SCORE: 0.5536

DSS_SCORE: 0.51

HELIX: 0.0728

FCONS_SCORE: 0.9732

RIG_SCORE: 0.6523

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S7L	DO233020	GACA	ICGC	IGPYYE	LIG_APCC_ABBA_1	0.2222
p.P3A	DO233035	GACA	ICGC	IGPYYE	LIG_APCC_ABBA_1	0.1111
p.G8R	DO50967	LICA	ICGC	IGPYYE	LIG_APCC_ABBA_1	0.25
p.E9G	DO25320	LUAD	ICGC	IGPYYE	LIG_APCC_ABBA_1	0.2778
p.L3F	DO36394	READ	ICGC	IGPYYE	LIG_APCC_ABBA_1	0.1111
p.E23K	ACH-001550	Skin Cancer	CCLE	IGPYYE	LIG_APCC_ABBA_1	0.1389
p.E23K	MCC13	skin	COSMIC	IGPYYE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15393	Transmembrane protease serine 2	LIG_APCC_ABBA_1	11:16	IGPYYE	APC,CDC20,FZR1	0.8787	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons