DegronMD

Uniprot ID: Q2M1K9

Source protein: Zinc finger protein 423

Source gene: ZNF423

Class: DEG_APCC_KENBOX_2

Location: 584:588

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9587

ASA_SCORE: 111.94

COIL: 0.8572

CONS_SCORE: 0.2802

DSS_SCORE: 0.3915

HELIX: 0.0166

FCONS_SCORE: 0.7791

RIG_SCORE: 0.758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N590S	TCGA-44-7662	LUAD	TCGA	IKENH	DEG_APCC_KENBOX_2	0.2778
p.I577F	TCGA-5C-AAPD	LIHC	TCGA	IKENH	DEG_APCC_KENBOX_2	0.1389
p.H595R	TCGA-AB-2854	LAML	TCGA	IKENH	DEG_APCC_KENBOX_2	0.1389
p.A594S	TCGA-AR-A251	BRCA	TCGA	IKENH	DEG_APCC_KENBOX_2	0.1667
p.H595Q	TCGA-B9-4116	KIRP	TCGA	IKENH	DEG_APCC_KENBOX_2	0.1389
p.H588Q	TCGA-DD-A1EL	LIHC	TCGA	IKENH	DEG_APCC_KENBOX_2	0.647
p.K589R	TCGA-VQ-A8P2	STAD	TCGA	IKENH	DEG_APCC_KENBOX_2	0.3056
p.L579F	DO23732	LUAD	ICGC	IKENH	DEG_APCC_KENBOX_2	0.3056
p.F581L	DO26112	LUAD	ICGC	IKENH	DEG_APCC_KENBOX_2	0.25
p.S586I	DO26608	LUSC	ICGC	IKENH	DEG_APCC_KENBOX_2	0.7341
p.K580N	DO34680	PACA	ICGC	IKENH	DEG_APCC_KENBOX_2	0.2222
p.G575V	SIDM00983	Bladder Carcinoma	GDSC	IKENH	DEG_APCC_KENBOX_2	0.0833
p.G575V	ACH-000896	Bladder Cancer	CCLE	IKENH	DEG_APCC_KENBOX_2	0.0833
p.G575V	647-V	urinary_tract	COSMIC	IKENH	DEG_APCC_KENBOX_2	0.0833
p.S596N	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	IKENH	DEG_APCC_KENBOX_2	0.1111
p.S596N	ACH-000852	Lung Cancer	CCLE	IKENH	DEG_APCC_KENBOX_2	0.1111
p.S596N	NCI-H1435	lung	COSMIC	IKENH	DEG_APCC_KENBOX_2	0.1111
p.E578K	IM-95	stomach	COSMIC	IKENH	DEG_APCC_KENBOX_2	0.1667
p.E578K	EC-GI-10	oesophagus	COSMIC	IKENH	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M1K9	Zinc finger protein 423	DEG_APCC_KENBOX_2	584:588	IKENH	APC,CDC20,FZR1	0.9587	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons