DegronMD

Uniprot ID: P61978

Source protein: Heterogeneous nuclear ribonucleoprotein K

Source gene: HNRNPK

Class: LIG_APCC_ABBA_1

Location: 178:183

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5017

ASA_SCORE: 66.3667

COIL: 0.3355

CONS_SCORE: 0.5525

DSS_SCORE: 0.2613

HELIX: 0.1038

FCONS_SCORE: 0.7869

RIG_SCORE: 0.8874

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R171Q	TCGA-BS-A0UV	UCEC	TCGA	IKLFQE	LIG_APCC_ABBA_1	0.1389
p.R171Q	DO40948	UCEC	ICGC	IKLFQE	LIG_APCC_ABBA_1	0.1389
p.R171Q	DO42793	UCEC	ICGC	IKLFQE	LIG_APCC_ABBA_1	0.1389
p.T189A	TCGA-BT-A2LA	BLCA	TCGA	IKLFQE	LIG_APCC_ABBA_1	0.1667
p.T189A	DO561	BLCA	ICGC	IKLFQE	LIG_APCC_ABBA_1	0.1667
p.I178M	TCGA-DK-A1AC	BLCA	TCGA	IKLFQE	LIG_APCC_ABBA_1	0.6507
p.I178M	DO514	BLCA	ICGC	IKLFQE	LIG_APCC_ABBA_1	0.6507
p.Q175K	DO234188	ESAD	ICGC	IKLFQE	LIG_APCC_ABBA_1	0.25
p.N173K	DO228986	LICA	ICGC	IKLFQE	LIG_APCC_ABBA_1	0.1944
p.C185F	DO46394	OV	ICGC	IKLFQE	LIG_APCC_ABBA_1	0.2778
p.Q182H	SIDM00789	Colorectal Carcinoma	GDSC	IKLFQE	LIG_APCC_ABBA_1	0.647
p.Q182H	ACH-000997	Colon/Colorectal Cancer	CCLE	IKLFQE	LIG_APCC_ABBA_1	0.647
p.Q182H	ACH-001061	Colon/Colorectal Cancer	CCLE	IKLFQE	LIG_APCC_ABBA_1	0.647
p.Q182H	HCT-15	large_intestine	COSMIC	IKLFQE	LIG_APCC_ABBA_1	0.647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P61978	Heterogeneous nuclear ribonucleoprotein K	LIG_APCC_ABBA_1	178:183	IKLFQE	APC,CDC20,FZR1	0.5017	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons