DegronMD

Uniprot ID: P12956

Source protein: X-ray repair cross-complementing protein 6

Source gene: XRCC6

Class: LIG_APCC_ABBA_1

Location: 286:291

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8922

ASA_SCORE: 81

COIL: 0.5068

CONS_SCORE: 0.4345

DSS_SCORE: 0.4305

HELIX: 0.031

FCONS_SCORE: 0.9754

RIG_SCORE: 0.7982

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K290N	HCC2998	large_intestine	COSMIC	IKLYRE	LIG_APCC_ABBA_1	0.6918
p.K282N	TCGA-AA-A010	COAD	TCGA	IKLYRE	LIG_APCC_ABBA_1	0.6667
p.I286V	COR-L321	NS	COSMIC	IKLYRE	LIG_APCC_ABBA_1	0.5965
p.K287Q	TCGA-E6-A1LX	UCEC	TCGA	IKLYRE	LIG_APCC_ABBA_1	0.5833
p.K287Q	DO41020	UCEC	ICGC	IKLYRE	LIG_APCC_ABBA_1	0.5833
p.P284S	TCGA-GD-A3OQ	BLCA	TCGA	IKLYRE	LIG_APCC_ABBA_1	0.2778
p.P284S	DO506	BLCA	ICGC	IKLYRE	LIG_APCC_ABBA_1	0.2778
p.R284C	HT-115	large_intestine	COSMIC	IKLYRE	LIG_APCC_ABBA_1	0.2778
p.E294D	TCGA-D8-A1XK	BRCA	TCGA	IKLYRE	LIG_APCC_ABBA_1	0.25
p.E294D	DO4749	BRCA	ICGC	IKLYRE	LIG_APCC_ABBA_1	0.25
p.K279R	DO228960	LICA	ICGC	IKLYRE	LIG_APCC_ABBA_1	0.25
p.P295S	DO218857	SKCA	ICGC	IKLYRE	LIG_APCC_ABBA_1	0.2222
p.V296M	TCGA-GF-A6C9	SKCM	TCGA	IKLYRE	LIG_APCC_ABBA_1	0.1944
p.V296M	DO51254	SKCM	ICGC	IKLYRE	LIG_APCC_ABBA_1	0.1944
p.K281N	HCC2998	large_intestine	COSMIC	IKLYRE	LIG_APCC_ABBA_1	0.1944
p.A280S	TCGA-CM-6171	COAD	TCGA	IKLYRE	LIG_APCC_ABBA_1	0.1667
p.A280S	DO8151	COAD	ICGC	IKLYRE	LIG_APCC_ABBA_1	0.1667
p.I277V	COR-L321	NS	COSMIC	IKLYRE	LIG_APCC_ABBA_1	0.0833

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12956	X-ray repair cross-complementing protein 6	LIG_APCC_ABBA_1	286:291	IKLYRE	APC,CDC20,FZR1	0.8922	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons