DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IKLYRE
Uniprot ID:
P12956
Source protein:
X-ray repair cross-complementing protein 6
Source gene:
XRCC6
Class:
LIG_APCC_ABBA_1
Location:
286:291
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8922
ASA_SCORE:
81
COIL:
0.5068
CONS_SCORE:
0.4345
DSS_SCORE:
0.4305
HELIX:
0.031
FCONS_SCORE:
0.9754
RIG_SCORE:
0.7982
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K282N
TCGA-AA-A010
COAD
TCGA
IKLYRE
LIG_APCC_ABBA_1
0.6667
p.A280S
TCGA-CM-6171
COAD
TCGA
IKLYRE
LIG_APCC_ABBA_1
0.1667
p.A280S
DO8151
COAD
ICGC
IKLYRE
LIG_APCC_ABBA_1
0.1667
p.E294D
TCGA-D8-A1XK
BRCA
TCGA
IKLYRE
LIG_APCC_ABBA_1
0.25
p.E294D
DO4749
BRCA
ICGC
IKLYRE
LIG_APCC_ABBA_1
0.25
p.K287Q
TCGA-E6-A1LX
UCEC
TCGA
IKLYRE
LIG_APCC_ABBA_1
0.5833
p.K287Q
DO41020
UCEC
ICGC
IKLYRE
LIG_APCC_ABBA_1
0.5833
p.P284S
TCGA-GD-A3OQ
BLCA
TCGA
IKLYRE
LIG_APCC_ABBA_1
0.2778
p.P284S
DO506
BLCA
ICGC
IKLYRE
LIG_APCC_ABBA_1
0.2778
p.V296M
TCGA-GF-A6C9
SKCM
TCGA
IKLYRE
LIG_APCC_ABBA_1
0.1944
p.V296M
DO51254
SKCM
ICGC
IKLYRE
LIG_APCC_ABBA_1
0.1944
p.K279R
DO228960
LICA
ICGC
IKLYRE
LIG_APCC_ABBA_1
0.25
p.P295S
DO218857
SKCA
ICGC
IKLYRE
LIG_APCC_ABBA_1
0.2222
p.K281N
HCC2998
large_intestine
COSMIC
IKLYRE
LIG_APCC_ABBA_1
0.1944
p.R284C
HT-115
large_intestine
COSMIC
IKLYRE
LIG_APCC_ABBA_1
0.2778
p.I277V
COR-L321
NS
COSMIC
IKLYRE
LIG_APCC_ABBA_1
0.0833
p.I286V
COR-L321
NS
COSMIC
IKLYRE
LIG_APCC_ABBA_1
0.5965
p.K290N
HCC2998
large_intestine
COSMIC
IKLYRE
LIG_APCC_ABBA_1
0.6918
Drug responses associated with XRCC6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IKLYRE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P12956
X-ray repair cross-complementing protein 6
LIG_APCC_ABBA_1
286:291
IKLYRE
APC,CDC20,FZR1
0.8922
More...