DegronMD

Uniprot ID: Q9BXT5

Source protein: Testis-expressed protein 15

Source gene: TEX15

Class: DEG_SCF_FBW7_1

Location: 86:93

E3 ligase: FBXW7

DEGRON score: 0.6996

ASA_SCORE: 83.8

COIL: 0.8984

CONS_SCORE: 0.4736

DSS_SCORE: 0.5739

HELIX: 0.054

FCONS_SCORE: 0.8736

RIG_SCORE: 0.6201

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S88L	TCGA-B5-A3FA	UCEC	TCGA	IKSTPSNS	DEG_SCF_FBW7_1	0.6556
p.S88L	TCGA-BF-AAP2	SKCM	TCGA	IKSTPSNS	DEG_SCF_FBW7_1	0.6556
p.S88L	TCGA-DF-A2KV	UCEC	TCGA	IKSTPSNS	DEG_SCF_FBW7_1	0.6556
p.S88L	TCGA-EE-A2MC	SKCM	TCGA	IKSTPSNS	DEG_SCF_FBW7_1	0.6556
p.S88L	DO37559	SKCM	ICGC	IKSTPSNS	DEG_SCF_FBW7_1	0.6556
p.S88L	DO219466	SKCM	ICGC	IKSTPSNS	DEG_SCF_FBW7_1	0.6556
p.S88L	DO219771	UCEC	ICGC	IKSTPSNS	DEG_SCF_FBW7_1	0.6556
p.S88L	DO52402	UCEC	ICGC	IKSTPSNS	DEG_SCF_FBW7_1	0.6556
p.E98V	TCGA-D1-A103	UCEC	TCGA	IKSTPSNS	DEG_SCF_FBW7_1	0.1944
p.E98V	DO42312	UCEC	ICGC	IKSTPSNS	DEG_SCF_FBW7_1	0.1944
p.I86K	TCGA-EB-A4IS	SKCM	TCGA	IKSTPSNS	DEG_SCF_FBW7_1	0.7531
p.I86K	DO47281	SKCM	ICGC	IKSTPSNS	DEG_SCF_FBW7_1	0.7531
p.G102C	TCGA-EE-A2MM	SKCM	TCGA	IKSTPSNS	DEG_SCF_FBW7_1	0.0833
p.G102C	DO37770	SKCM	ICGC	IKSTPSNS	DEG_SCF_FBW7_1	0.0833
p.S78G	ACH-000399	Lung Cancer	CCLE	IKSTPSNS	DEG_SCF_FBW7_1	0.1111
p.S78G	NCI-H2196	lung	COSMIC	IKSTPSNS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXT5	Testis-expressed protein 15	DEG_SCF_FBW7_1	86:93	IKSTPSNS	FBXW7	0.6996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons