DegronMD

Uniprot ID: P46940

Source protein: Ras GTPase-activating-like protein IQGAP1

Source gene: IQGAP1

Class: DEG_SCF_FBW7_1

Location: 1407:1414

E3 ligase: FBXW7

DEGRON score: 0.8631

ASA_SCORE: 53.6875

COIL: 0.5779

CONS_SCORE: 0.4274

DSS_SCORE: 0.5778

HELIX: 0.4154

FCONS_SCORE: 1.0522

RIG_SCORE: 0.7486

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1423V	TCGA-EE-A3JD	SKCM	TCGA	ILETPATS	DEG_SCF_FBW7_1	0.0833
p.P1411S	SIDM01101	Neuroblastoma	GDSC	ILETPATS	DEG_SCF_FBW7_1	0.6752
p.P1411S	SIDM01777	Pancreatic Carcinoma	GDSC	ILETPATS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46940	Ras GTPase-activating-like protein IQGAP1	DEG_SCF_FBW7_1	1407:1414	ILETPATS	FBXW7	0.8631	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons