DegronMD

Uniprot ID: Q96S95

Source protein: Calcium/calmodulin-dependent protein kinase II inhibitor 2

Source gene: CAMK2N2

Class: LIG_APCC_ABBA_1

Location: 4:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9989

ASA_SCORE: 78.2

COIL: 0.8507

CONS_SCORE: 0.8893

DSS_SCORE: 0.6563

HELIX: 0.09

FCONS_SCORE: 1.0674

RIG_SCORE: 0.7648

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D18H	TCGA-AA-3947	COAD	TCGA	ILPYSE	LIG_APCC_ABBA_1	0.0833
p.D18H	DO8192	COAD	ICGC	ILPYSE	LIG_APCC_ABBA_1	0.0833
p.G16C	TCGA-D7-6525	STAD	TCGA	ILPYSE	LIG_APCC_ABBA_1	0.1389
p.G16C	DO38783	STAD	ICGC	ILPYSE	LIG_APCC_ABBA_1	0.1389
p.R14L	TCGA-EJ-A65F	PRAD	TCGA	ILPYSE	LIG_APCC_ABBA_1	0.1944
p.R14L	DO51315	PRAD	ICGC	ILPYSE	LIG_APCC_ABBA_1	0.1944
p.P6L	TCGA-ZB-A966	THYM	TCGA	ILPYSE	LIG_APCC_ABBA_1	0.6471
p.S8G	SIDM00393	Gastric Carcinoma	GDSC	ILPYSE	LIG_APCC_ABBA_1	0.6993
p.S8G	ACH-001653	Gastric Cancer	CCLE	ILPYSE	LIG_APCC_ABBA_1	0.6993
p.K11R	ACH-001610	Brain Cancer	CCLE	ILPYSE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96S95	Calcium/calmodulin-dependent protein kinase II inhibitor 2	LIG_APCC_ABBA_1	4:9	ILPYSE	APC,CDC20,FZR1	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons