DegronMD

Uniprot ID: Q9HC38

Source protein: Glyoxalase domain-containing protein 4

Source gene: GLOD4

Class: DEG_SCF_FBW7_1

Location: 240:246

E3 ligase: FBXW7

DEGRON score: 0.9184

ASA_SCORE: 43.9571

COIL: 0.5004

CONS_SCORE: 0.6392

DSS_SCORE: 0.3704

HELIX: 0.0273

FCONS_SCORE: 1.0447

RIG_SCORE: 0.8125

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P235L	TCGA-C5-A902	CESC	TCGA	ILTPLVS	DEG_SCF_FBW7_1	0.1944
p.L245M	TCGA-DZ-6132	KIRP	TCGA	ILTPLVS	DEG_SCF_FBW7_1	0.711
p.P235Q	TCGA-EE-A181	SKCM	TCGA	ILTPLVS	DEG_SCF_FBW7_1	0.1944
p.P248T	TCGA-ER-A1A1	SKCM	TCGA	ILTPLVS	DEG_SCF_FBW7_1	0.2778
p.I244S	TCGA-IE-A3OV	SARC	TCGA	ILTPLVS	DEG_SCF_FBW7_1	0.7341
p.P250L	DO49916	CESC	ICGC	ILTPLVS	DEG_SCF_FBW7_1	0.2222
p.V245L	DO234417	ESAD	ICGC	ILTPLVS	DEG_SCF_FBW7_1	0.5654
p.R235S	DO20853	KIRP	ICGC	ILTPLVS	DEG_SCF_FBW7_1	0.1944
p.S246R	DO228986	LICA	ICGC	ILTPLVS	DEG_SCF_FBW7_1	0.8538
p.A253E	DO229035	LICA	ICGC	ILTPLVS	DEG_SCF_FBW7_1	0.1389
p.P239T	DO37413	SKCM	ICGC	ILTPLVS	DEG_SCF_FBW7_1	0.75
p.P250Q	DO37444	SKCM	ICGC	ILTPLVS	DEG_SCF_FBW7_1	0.2222
p.L255F	DO38016	SKCM	ICGC	ILTPLVS	DEG_SCF_FBW7_1	0.0833
p.D247N	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	ILTPLVS	DEG_SCF_FBW7_1	0.3056
p.D247N	ACH-000869	Lung Cancer	CCLE	ILTPLVS	DEG_SCF_FBW7_1	0.3056
p.D247N	NCI-H1568	lung	COSMIC	ILTPLVS	DEG_SCF_FBW7_1	0.3056
p.I253L	SIDM01588	Endometrial Carcinoma	GDSC	ILTPLVS	DEG_SCF_FBW7_1	0.1389
p.I253L	ACH-000993	Endometrial/Uterine Cancer	CCLE	ILTPLVS	DEG_SCF_FBW7_1	0.1389
p.A247T	NCI-H1581	lung	COSMIC	ILTPLVS	DEG_SCF_FBW7_1	0.3056
p.M233I	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	ILTPLVS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC38	Glyoxalase domain-containing protein 4	DEG_SCF_FBW7_1	240:246	ILTPLVS	FBXW7	0.9184	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons