DegronMD

Uniprot ID: Q9UKF6

Source protein: Cleavage and polyadenylation specificity factor subunit 3

Source gene: CPSF3

Class: LIG_APCC_ABBA_1

Location: 415:420

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8522

ASA_SCORE: 21.15

COIL: 0.4778

CONS_SCORE: 0.706

DSS_SCORE: 0.3144

HELIX: 0.0098

FCONS_SCORE: 1.7512

RIG_SCORE: 0.8017

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K410T	TCGA-44-3918	LUAD	TCGA	ILVHGE	LIG_APCC_ABBA_1	0.6389
p.P411L	TCGA-44-3918	LUAD	TCGA	ILVHGE	LIG_APCC_ABBA_1	0.2222
p.L427F	TCGA-95-7567	LUAD	TCGA	ILVHGE	LIG_APCC_ABBA_1	0.1389
p.R407C	TCGA-BT-A3PH	BLCA	TCGA	ILVHGE	LIG_APCC_ABBA_1	0.1111
p.E423K	TCGA-C5-A7XC	CESC	TCGA	ILVHGE	LIG_APCC_ABBA_1	0.25
p.H418N	TCGA-D3-A3CB	SKCM	TCGA	ILVHGE	LIG_APCC_ABBA_1	0.7423
p.R412Q	DO233116	GACA	ICGC	ILVHGE	LIG_APCC_ABBA_1	0.25
p.A416T	DO16769	KIRC	ICGC	ILVHGE	LIG_APCC_ABBA_1	0.7139
p.V408F	DO229029	LICA	ICGC	ILVHGE	LIG_APCC_ABBA_1	0.1389
p.R412W	DO45346	LUAD	ICGC	ILVHGE	LIG_APCC_ABBA_1	0.25
p.R412W	DO36531	READ	ICGC	ILVHGE	LIG_APCC_ABBA_1	0.25
p.V408A	DO222837	MELA	ICGC	ILVHGE	LIG_APCC_ABBA_1	0.1389
p.Q421E	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	ILVHGE	LIG_APCC_ABBA_1	0.3056
p.Q421E	ACH-000873	Esophageal Cancer	CCLE	ILVHGE	LIG_APCC_ABBA_1	0.3056
p.Q421E	KYSE-270	oesophagus	COSMIC	ILVHGE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKF6	Cleavage and polyadenylation specificity factor subunit 3	LIG_APCC_ABBA_1	415:420	ILVHGE	APC,CDC20,FZR1	0.8522	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons