DegronMD

Uniprot ID: Q92616

Source protein: eIF-2-alpha kinase activator GCN1

Source gene: GCN1

Class: DEG_SCF_FBW7_2

Location: 765:772

E3 ligase: FBXW7

DEGRON score: 0.9124

ASA_SCORE: 52.675

COIL: 0.634

CONS_SCORE: 0.4458

DSS_SCORE: 0.2617

HELIX: 0.3113

FCONS_SCORE: 1.2733

RIG_SCORE: 0.7841

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A764S	SIDM01196	Hepatocellular Carcinoma	GDSC	IMQTPAGE	DEG_SCF_FBW7_2	0.3056
p.A764S	SNU-475	liver	COSMIC	IMQTPAGE	DEG_SCF_FBW7_2	0.3056
p.R760Q	SIDM00999	Bladder Carcinoma	GDSC	IMQTPAGE	DEG_SCF_FBW7_2	0.1944
p.R760Q	639-V	urinary_tract	COSMIC	IMQTPAGE	DEG_SCF_FBW7_2	0.1944
p.R756H	SIDM01729	Endometrial Carcinoma	GDSC	IMQTPAGE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92616	eIF-2-alpha kinase activator GCN1	DEG_SCF_FBW7_2	765:772	IMQTPAGE	FBXW7	0.9124	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons