DegronMD

Uniprot ID: Q9Y2I7

Source protein: 1-phosphatidylinositol 3-phosphate 5-kinase

Source gene: PIKFYVE

Class: LIG_APCC_ABBA_1

Location: 1805:1810

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8578

ASA_SCORE: 66.15

COIL: 0.4383

CONS_SCORE: 0.326

DSS_SCORE: 0.413

HELIX: 0.0345

FCONS_SCORE: 1.0319

RIG_SCORE: 0.8165

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1799I	TCGA-19-5956	GBM	TCGA	INPHVE	LIG_APCC_ABBA_1	0.1667
p.T1799I	TCGA-AA-3845	COAD	TCGA	INPHVE	LIG_APCC_ABBA_1	0.1667
p.T1799I	TCGA-KN-8428	KICH	TCGA	INPHVE	LIG_APCC_ABBA_1	0.1667
p.T1799I	DO10020	COAD	ICGC	INPHVE	LIG_APCC_ABBA_1	0.1667
p.T1799I	DO228123	EOPC	ICGC	INPHVE	LIG_APCC_ABBA_1	0.1667
p.T1799I	DO13863	GBM	ICGC	INPHVE	LIG_APCC_ABBA_1	0.1667
p.T1799I	DO220484	KICH	ICGC	INPHVE	LIG_APCC_ABBA_1	0.1667
p.T1799I	ACH-001061	Colon/Colorectal Cancer	CCLE	INPHVE	LIG_APCC_ABBA_1	0.1667
p.Q1800K	TCGA-32-2494	GBM	TCGA	INPHVE	LIG_APCC_ABBA_1	0.1944
p.Q1800K	DO11998	GBM	ICGC	INPHVE	LIG_APCC_ABBA_1	0.1944
p.A1818S	TCGA-34-5236	LUSC	TCGA	INPHVE	LIG_APCC_ABBA_1	0.1111
p.A1818S	DO26778	LUSC	ICGC	INPHVE	LIG_APCC_ABBA_1	0.1111
p.K1801N	TCGA-AG-A002	READ	TCGA	INPHVE	LIG_APCC_ABBA_1	0.3333
p.S1814L	TCGA-AZ-6598	COAD	TCGA	INPHVE	LIG_APCC_ABBA_1	0.2222
p.S1814L	DO10276	COAD	ICGC	INPHVE	LIG_APCC_ABBA_1	0.2222
p.S1814L	DO229272	THCA	ICGC	INPHVE	LIG_APCC_ABBA_1	0.2222
p.P1807S	TCGA-FS-A1ZZ	SKCM	TCGA	INPHVE	LIG_APCC_ABBA_1	0.6752
p.P1807S	DO37412	SKCM	ICGC	INPHVE	LIG_APCC_ABBA_1	0.6752
p.K1819N	DO228974	LICA	ICGC	INPHVE	LIG_APCC_ABBA_1	0.1944
p.D1798Y	DO229029	LICA	ICGC	INPHVE	LIG_APCC_ABBA_1	0.1389
p.I1805L	DO222847	MELA	ICGC	INPHVE	LIG_APCC_ABBA_1	0.6063
p.Q1803K	DO229213	THCA	ICGC	INPHVE	LIG_APCC_ABBA_1	0.2778
p.I1805T	SIDM00845	Burkitt's Lymphoma	GDSC	INPHVE	LIG_APCC_ABBA_1	0.7078
p.I1805T	SIDM01519	Head and Neck Carcinoma	GDSC	INPHVE	LIG_APCC_ABBA_1	0.7078
p.D1795H	ACH-000923	Lymphoma	CCLE	INPHVE	LIG_APCC_ABBA_1	0.0556
p.P1807H	ACH-000946	Endometrial/Uterine Cancer	CCLE	INPHVE	LIG_APCC_ABBA_1	0.7694

Drug responses associated with PIKFYVE mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00918	OV\|ovary	p.R572Q (No)	GDSC	YM201636	14.9278
SIDM00889	CESC\|cervix	p.E829fs*1 (No)	GDSC	YM201636	1.7478
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A1827T (No)	GDSC	YM201636	1.5959
SIDM01029	ESCA\|oesophagus	p.V2051L (No)	GDSC	YM201636	6.3411
SIDM00213	THCA\|thyroid	p.P1521H (No)	GDSC	YM201636	75.4698
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R1881S (No)	GDSC	YM201636	10.9164
SIDM00499	PRAD\|prostate	p.I229V (No)	GDSC	YM201636	3.5303
SIDM00967	OV\|ovary	p.P818S (No)	GDSC	YM201636	8.4389
SIDM00754	LUAD\|lung_NSCLC_adenocarcinoma	p.I667M (No)	GDSC	YM201636	69.5696
SIDM00901	UCEC\|endometrium	p.A512V (No)	GDSC	YM201636	6.2194
SIDM00957	COREAD\|large_intestine	p.L2094F (No)	GDSC	YM201636	61.6263
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.R176H (No)	GDSC	YM201636	4.1383
SIDM00859	DLBC\|B_cell_lymphoma	p.P77S (No)	GDSC	YM201636	0.4883
SIDM00877	BRCA\|breast	p.H1364D (No)	GDSC	YM201636	3.335
SIDM00620	LGG\|glioma	p.T1764N (No)	GDSC	YM201636	4.7794
SIDM00250	ESCA\|oesophagus	p.T1564A (No)	GDSC	YM201636	40.7615
SIDM00527	COREAD\|large_intestine	p.V337F (No)	GDSC	YM201636	10.9964
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A901G (No)	GDSC	YM201636	4.6072
SIDM01007	ALL\|lymphoblastic_leukemia	p.Y46H (No)	GDSC	YM201636	2.4259
SIDM01007	ALL\|lymphoblastic_leukemia	p.A878S (No)	GDSC	YM201636	2.4259
SIDM01007	ALL\|lymphoblastic_leukemia	p.F1606L (No)	GDSC	YM201636	2.4259
SIDM00664	PAAD\|pancreas	p.V652I (No)	GDSC	YM201636	126.841
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.V902F (No)	GDSC	YM201636	68.7086
SIDM00466	OV\|ovary	p.M1473L (No)	GDSC	YM201636	2.1923
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.Q293P (No)	GDSC	YM201636	0.9244
SIDM00214	COREAD\|large_intestine	p.A691V (No)	GDSC	YM201636	2.354
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.P1593R (No)	GDSC	YM201636	1.9314
SIDM01045	UCEC\|endometrium	p.K162N (No)	GDSC	YM201636	5.7846
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.P450S (No)	GDSC	YM201636	56.3953
SIDM00256	NB\|neuroblastoma	p.K1446E (No)	GDSC	YM201636	3.3857
SIDM00217	COREAD\|large_intestine	p.A106V (No)	GDSC	YM201636	5.0645
SIDM00681	COREAD\|large_intestine	p.E1793V (No)	GDSC	YM201636	4.7949
SIDM00839	COREAD\|large_intestine	p.L2094F (No)	GDSC	YM201636	28.3603
SIDM00216	COREAD\|large_intestine	p.A513T (No)	GDSC	YM201636	1.5906
SIDM00216	COREAD\|large_intestine	p.R1560H (No)	GDSC	YM201636	1.5906
SIDM00282	COREAD\|large_intestine	p.Y1026H (No)	GDSC	YM201636	21.7007
SIDM00282	COREAD\|large_intestine	p.S1034Y (No)	GDSC	YM201636	21.7007
SIDM00637	DLBC\|B_cell_lymphoma	p.S1474F (No)	GDSC	YM201636	2.0845
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E894V (No)	GDSC	YM201636	3.7282
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.I1427V (No)	GDSC	YM201636	2.0036
SIDM00257	NB\|neuroblastoma	p.A965G (No)	GDSC	YM201636	2.6281
SIDM00382	GBM\|glioma	p.D1604fs*15 (No)	GDSC	YM201636	13.1669
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.M859V (No)	GDSC	YM201636	10.5899
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.E920* (No)	GDSC	YM201636	10.5899
SIDM00789	COREAD\|large_intestine	p.R375C (No)	GDSC	YM201636	10.4792
SIDM00789	COREAD\|large_intestine	p.I1898F (No)	GDSC	YM201636	10.4792
SIDM00273	LGG\|glioma	p.G460R (No)	GDSC	YM201636	6.0988
SIDM00487	COREAD\|large_intestine	p.D12G (No)	GDSC	YM201636	4.5961
SIDM01169	OV\|ovary	p.R1401H (No)	GDSC	YM201636	26.7747
SIDM00255	NB\|neuroblastoma	p.V1279L (No)	GDSC	YM201636	5.2676
SIDM00114	MESO\|mesothelioma	p.S628L (No)	GDSC	YM201636	3.5121
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A1674T (No)	GDSC	YM201636	5.4175
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.S514C (No)	GDSC	YM201636	7.092
SIDM00127	HNSC\|head_and_neck	p.R1546L (No)	GDSC	YM201636	10.6644
SIDM01138	PAAD\|pancreas	p.S639L (No)	GDSC	YM201636	13.7477
SIDM00285	NB\|neuroblastoma	p.T1571N (No)	GDSC	YM201636	5.2611
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.E1654D (No)	GDSC	YM201636	24.1933
SIDM00581	GBM\|glioma	p.P584L (No)	GDSC	YM201636	7.3773
SIDM01259	ALL\|lymphoblastic_leukemia	p.R1284H (No)	GDSC	YM201636	1.5408
SIDM00537	COREAD\|large_intestine	p.R54C (No)	GDSC	YM201636	3.208
SIDM00537	COREAD\|large_intestine	p.V290A (No)	GDSC	YM201636	3.208
SIDM00537	COREAD\|large_intestine	p.A1378V (No)	GDSC	YM201636	3.208
SIDM01246	NB\|neuroblastoma	p.H536P (No)	GDSC	YM201636	4.5459
SIDM00384	DLBC\|B_cell_lymphoma	p.L419M (No)	GDSC	YM201636	5.5032
SIDM00837	COREAD\|large_intestine	p.R379I (No)	GDSC	YM201636	21.8994
SIDM00238	OV\|ovary	p.S88P (No)	GDSC	YM201636	9.4778
SIDM00238	OV\|ovary	p.M605T (No)	GDSC	YM201636	9.4778
SIDM00238	OV\|ovary	p.Y1650H (No)	GDSC	YM201636	9.4778
SIDM00113	KIRC\|kidney	p.Q331H (No)	GDSC	YM201636	24.1926
SIDM00817	KIRC\|kidney	p.T1205A (No)	GDSC	YM201636	38.0465
SIDM00852	LGG\|glioma	p.Q987H (No)	GDSC	YM201636	24.2634

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: INPHVE

Degron related mutations and impact score

Drug responses associated with PIKFYVE mutations

All proteins holding degron of INPHVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	LIG_APCC_ABBA_1	1805:1810	INPHVE	APC,CDC20,FZR1	0.8578	More...