DegronMD

Uniprot ID: Q9GZS0

Source protein: Dynein axonemal intermediate chain 2

Source gene: DNAI2

Class: LIG_APCC_ABBA_1

Location: 152:157

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7743

ASA_SCORE: 43.2

COIL: 0.428

CONS_SCORE: 0.6347

DSS_SCORE: 0.4808

HELIX: 0.0197

FCONS_SCORE: 1.2289

RIG_SCORE: 0.8101

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V142L	TCGA-55-8506	LUAD	TCGA	INVFRD	LIG_APCC_ABBA_1	0.0556
p.T151I	TCGA-AX-A1C5	UCEC	TCGA	INVFRD	LIG_APCC_ABBA_1	0.3056
p.K162N	TCGA-C5-A1MH	CESC	TCGA	INVFRD	LIG_APCC_ABBA_1	0.3056
p.A165V	TCGA-D1-A160	UCEC	TCGA	INVFRD	LIG_APCC_ABBA_1	0.1111
p.A165V	TCGA-DA-A95Z	SKCM	TCGA	INVFRD	LIG_APCC_ABBA_1	0.1111
p.V142M	TCGA-D1-A17Q	UCEC	TCGA	INVFRD	LIG_APCC_ABBA_1	0.0556
p.V142M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	INVFRD	LIG_APCC_ABBA_1	0.0556
p.P147H	TCGA-D3-A2JN	SKCM	TCGA	INVFRD	LIG_APCC_ABBA_1	0.1944
p.P147H	TCGA-EE-A2GR	SKCM	TCGA	INVFRD	LIG_APCC_ABBA_1	0.1944
p.E160K	TCGA-D3-A8GM	SKCM	TCGA	INVFRD	LIG_APCC_ABBA_1	0.25
p.E160K	TCGA-D9-A4Z3	SKCM	TCGA	INVFRD	LIG_APCC_ABBA_1	0.25
p.E144Q	TCGA-IR-A3LA	CESC	TCGA	INVFRD	LIG_APCC_ABBA_1	0.1111
p.Q159R	TCGA-KD-A5QU	SARC	TCGA	INVFRD	LIG_APCC_ABBA_1	0.2778
p.V164I	DO7828	COAD	ICGC	INVFRD	LIG_APCC_ABBA_1	0.1389
p.A166T	DO8634	COAD	ICGC	INVFRD	LIG_APCC_ABBA_1	0.0833
p.A166T	DO50657	ORCA	ICGC	INVFRD	LIG_APCC_ABBA_1	0.0833
p.R154W	DO44950	LIHC	ICGC	INVFRD	LIG_APCC_ABBA_1	0.8634
p.R154W	DO41572	UCEC	ICGC	INVFRD	LIG_APCC_ABBA_1	0.8634
p.R154Q	DO50803	LIRI	ICGC	INVFRD	LIG_APCC_ABBA_1	0.7329
p.Q149L	DO24275	LUAD	ICGC	INVFRD	LIG_APCC_ABBA_1	0.25
p.R154L	DO50279	SKCM	ICGC	INVFRD	LIG_APCC_ABBA_1	0.8428
p.K155N	DO41542	UCEC	ICGC	INVFRD	LIG_APCC_ABBA_1	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9GZS0	Dynein axonemal intermediate chain 2	LIG_APCC_ABBA_1	152:157	INVFRD	APC,CDC20,FZR1	0.7743	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons