DegronMD

Uniprot ID: P02751

Source protein: Fibronectin

Source gene: FN1

Class: LIG_APCC_ABBA_1

Location: 1309:1314

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8502

ASA_SCORE: 72.6167

COIL: 0.2633

CONS_SCORE: 0.5164

DSS_SCORE: 0.0703

HELIX: 0.003

FCONS_SCORE: 1.193

RIG_SCORE: 0.9025

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1319L	TCGA-99-8025	LUAD	TCGA	IPIFED	LIG_APCC_ABBA_1	0.1944
p.S1319L	DO24255	LUAD	ICGC	IPIFED	LIG_APCC_ABBA_1	0.1944
p.R1299C	TCGA-AP-A0LM	UCEC	TCGA	IPIFED	LIG_APCC_ABBA_1	0.0556
p.R1299C	DO43306	UCEC	ICGC	IPIFED	LIG_APCC_ABBA_1	0.0556
p.R1299H	TCGA-B5-A3FA	UCEC	TCGA	IPIFED	LIG_APCC_ABBA_1	0.0556
p.R1299H	TCGA-CG-4305	STAD	TCGA	IPIFED	LIG_APCC_ABBA_1	0.0556
p.R1299H	DO38823	STAD	ICGC	IPIFED	LIG_APCC_ABBA_1	0.0556
p.R1299H	DO52402	UCEC	ICGC	IPIFED	LIG_APCC_ABBA_1	0.0556
p.R1299H	SIDM02041	Colorectal Carcinoma	GDSC	IPIFED	LIG_APCC_ABBA_1	0.0556
p.V1316A	TCGA-BR-8361	STAD	TCGA	IPIFED	LIG_APCC_ABBA_1	0.2778
p.V1316A	DO48032	STAD	ICGC	IPIFED	LIG_APCC_ABBA_1	0.2778
p.T1324A	TCGA-G4-6588	COAD	TCGA	IPIFED	LIG_APCC_ABBA_1	0.0556
p.T1324A	DO10140	COAD	ICGC	IPIFED	LIG_APCC_ABBA_1	0.0556
p.R1299S	TCGA-GN-A262	SKCM	TCGA	IPIFED	LIG_APCC_ABBA_1	0.0556
p.R1299S	DO229019	LICA	ICGC	IPIFED	LIG_APCC_ABBA_1	0.0556
p.R1299S	DO37515	SKCM	ICGC	IPIFED	LIG_APCC_ABBA_1	0.0556
p.L1299M	DO223732	CESC	ICGC	IPIFED	LIG_APCC_ABBA_1	0.0556
p.E1313D	DO224616	COCA	ICGC	IPIFED	LIG_APCC_ABBA_1	0.5647
p.P1318H	DO49694	LIHC	ICGC	IPIFED	LIG_APCC_ABBA_1	0.2222
p.S1317Y	DO43578	UCEC	ICGC	IPIFED	LIG_APCC_ABBA_1	0.25
p.E1313Q	SIDM01160	Bladder Carcinoma	GDSC	IPIFED	LIG_APCC_ABBA_1	0.5633
p.E1313Q	ACH-000384	Bladder Cancer	CCLE	IPIFED	LIG_APCC_ABBA_1	0.5633
p.E1313Q	SW780	urinary_tract	COSMIC	IPIFED	LIG_APCC_ABBA_1	0.5633

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02751	Fibronectin	LIG_APCC_ABBA_1	1309:1314	IPIFED	APC,CDC20,FZR1	0.8502	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons