DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IPLTPSTS
Uniprot ID:
Q8TF27
Source protein:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11
Source gene:
AGAP11
Class:
DEG_SCF_FBW7_1
Location:
57:64
E3 ligase:
FBXW7
DEGRON score:
0.9647
ASA_SCORE:
71.8625
COIL:
0.9145
CONS_SCORE:
0.2723
DSS_SCORE:
0.4108
HELIX:
0.0389
FCONS_SCORE:
0.8714
RIG_SCORE:
0.6687
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with AGAP11 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IPLTPSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8TF27
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11
DEG_SCF_FBW7_1
57:64
IPLTPSTS
FBXW7
0.9647
More...