DegronMD

Uniprot ID: O75417

Source protein: DNA polymerase theta

Source gene: POLQ

Class: DEG_SCF_FBW7_1

Location: 1735:1742

E3 ligase: FBXW7

DEGRON score: 0.9901

ASA_SCORE: 87.6125

COIL: 0.9621

CONS_SCORE: 0.2223

DSS_SCORE: 0.51

HELIX: 0.0134

FCONS_SCORE: 1.0251

RIG_SCORE: 0.6992

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1733D	TCGA-B5-A3FA	UCEC	TCGA	IPPTPIPT	DEG_SCF_FBW7_1	0.2778
p.G1733D	DO52402	UCEC	ICGC	IPPTPIPT	DEG_SCF_FBW7_1	0.2778
p.P1741Q	DO229015	LICA	ICGC	IPPTPIPT	DEG_SCF_FBW7_1	0.5924
p.T1738K	DO229022	LICA	ICGC	IPPTPIPT	DEG_SCF_FBW7_1	0.7306
p.G1751W	SIDM00773	Non-Cancerous	GDSC	IPPTPIPT	DEG_SCF_FBW7_1	0.0833
p.G1751W	SIDM00849	Kidney Carcinoma	GDSC	IPPTPIPT	DEG_SCF_FBW7_1	0.0833
p.G1751W	SIDM00774	Breast Carcinoma	GDSC	IPPTPIPT	DEG_SCF_FBW7_1	0.0833
p.G1751W	SIDM01409	Bladder Carcinoma	GDSC	IPPTPIPT	DEG_SCF_FBW7_1	0.0833
p.T1748S	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	IPPTPIPT	DEG_SCF_FBW7_1	0.1667
p.T1748S	ACH-000945	Lung Cancer	CCLE	IPPTPIPT	DEG_SCF_FBW7_1	0.1667
p.T1748S	NCI-H650	lung	COSMIC	IPPTPIPT	DEG_SCF_FBW7_1	0.1667
p.D1730N	SIDM00988	Kidney Carcinoma	GDSC	IPPTPIPT	DEG_SCF_FBW7_1	0.1944
p.D1730N	ACH-000792	Kidney Cancer	CCLE	IPPTPIPT	DEG_SCF_FBW7_1	0.1944
p.D1730N	BFTC-909	kidney	COSMIC	IPPTPIPT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75417	DNA polymerase theta	DEG_SCF_FBW7_1	1735:1742	IPPTPIPT	FBXW7	0.9901	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons