DegronMD

Uniprot ID: Q9NR09

Source protein: Baculoviral IAP repeat-containing protein 6

Source gene: BIRC6

Class: DEG_SCF_FBW7_1

Location: 1694:1701

E3 ligase: FBXW7

DEGRON score: 0.9861

ASA_SCORE: 73.875

COIL: 0.9349

CONS_SCORE: 0.4115

DSS_SCORE: 0.4262

HELIX: 0.0353

FCONS_SCORE: 1.027

RIG_SCORE: 0.6943

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1696S	TCGA-EE-A3AC	SKCM	TCGA	IPPTPKTT	DEG_SCF_FBW7_1	0.5641
p.P1696S	DO37631	SKCM	ICGC	IPPTPKTT	DEG_SCF_FBW7_1	0.5641
p.H1689Y	TCGA-FW-A3R5	SKCM	TCGA	IPPTPKTT	DEG_SCF_FBW7_1	0.1944
p.H1689Y	DO37406	SKCM	ICGC	IPPTPKTT	DEG_SCF_FBW7_1	0.1944
p.I1694F	TCGA-T2-A6WZ	HNSC	TCGA	IPPTPKTT	DEG_SCF_FBW7_1	0.7415
p.I1694F	DO219067	HNSC	ICGC	IPPTPKTT	DEG_SCF_FBW7_1	0.7415
p.V1693A	DO222798	COCA	ICGC	IPPTPKTT	DEG_SCF_FBW7_1	0.3056
p.G1685V	DO229027	LICA	ICGC	IPPTPKTT	DEG_SCF_FBW7_1	0.0833
p.P1690L	DO229058	LICA	ICGC	IPPTPKTT	DEG_SCF_FBW7_1	0.2222
p.T1701S	DO45119	LIRI	ICGC	IPPTPKTT	DEG_SCF_FBW7_1	0.6005
p.T1700I	DO51535	PACA	ICGC	IPPTPKTT	DEG_SCF_FBW7_1	0.5966
p.T1701I	DO229544	UTCA	ICGC	IPPTPKTT	DEG_SCF_FBW7_1	0.7078
p.I1688V	SIDM01447	Glioblastoma	GDSC	IPPTPKTT	DEG_SCF_FBW7_1	0.1667
p.I1688V	ACH-000289	Brain Cancer	CCLE	IPPTPKTT	DEG_SCF_FBW7_1	0.1667
p.I1694V	ACH-000419	Myeloma	CCLE	IPPTPKTT	DEG_SCF_FBW7_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR09	Baculoviral IAP repeat-containing protein 6	DEG_SCF_FBW7_1	1694:1701	IPPTPKTT	FBXW7	0.9861	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons