DegronMD

Uniprot ID: Q8WUY3

Source protein: Protein prune homolog 2

Source gene: PRUNE2

Class: DEG_SCF_FBW7_1

Location: 608:615

E3 ligase: FBXW7

DEGRON score: 0.9977

ASA_SCORE: 74.625

COIL: 0.908

CONS_SCORE: 0.5884

DSS_SCORE: 0.7042

HELIX: 0.0469

FCONS_SCORE: 1.2228

RIG_SCORE: 0.6291

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S620L	TCGA-FR-A726	SKCM	TCGA	IPPTPMNS	DEG_SCF_FBW7_1	0.1944
p.S602Y	DO3524	BRCA	ICGC	IPPTPMNS	DEG_SCF_FBW7_1	0.2778
p.S599L	DO8842	COAD	ICGC	IPPTPMNS	DEG_SCF_FBW7_1	0.0833
p.S599L	DO37444	SKCM	ICGC	IPPTPMNS	DEG_SCF_FBW7_1	0.0833
p.S599L	DO43306	UCEC	ICGC	IPPTPMNS	DEG_SCF_FBW7_1	0.0833
p.S599L	DO41572	UCEC	ICGC	IPPTPMNS	DEG_SCF_FBW7_1	0.0833
p.S599L	DO41235	UCEC	ICGC	IPPTPMNS	DEG_SCF_FBW7_1	0.0833
p.S599L	DO41133	UCEC	ICGC	IPPTPMNS	DEG_SCF_FBW7_1	0.0833
p.E623K	DO229016	COCA	ICGC	IPPTPMNS	DEG_SCF_FBW7_1	0.1111
p.E623K	DO222908	MELA	ICGC	IPPTPMNS	DEG_SCF_FBW7_1	0.1111
p.S609Y	DO231887	LINC	ICGC	IPPTPMNS	DEG_SCF_FBW7_1	0.712
p.S599P	DO220851	MELA	ICGC	IPPTPMNS	DEG_SCF_FBW7_1	0.0833
p.D598N	DO229456	SKCA	ICGC	IPPTPMNS	DEG_SCF_FBW7_1	0.0556
p.G621R	DO47413	SKCM	ICGC	IPPTPMNS	DEG_SCF_FBW7_1	0.1667
p.K606N	SIDM00892	Breast Carcinoma	GDSC	IPPTPMNS	DEG_SCF_FBW7_1	0.2778
p.K606N	ACH-000818	Breast Cancer	CCLE	IPPTPMNS	DEG_SCF_FBW7_1	0.2778
p.K606N	BT-483	breast	COSMIC	IPPTPMNS	DEG_SCF_FBW7_1	0.2778
p.E618Q	ACH-000836	Head and Neck Cancer	CCLE	IPPTPMNS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUY3	Protein prune homolog 2	DEG_SCF_FBW7_1	608:615	IPPTPMNS	FBXW7	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons