DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IPPTPSTS
Uniprot ID:
Q5VTM2
Source protein:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9
Source gene:
AGAP9
Class:
DEG_SCF_FBW7_1
Location:
263:270
E3 ligase:
FBXW7
DEGRON score:
0.9858
ASA_SCORE:
75.925
COIL:
0.9484
CONS_SCORE:
0.2918
DSS_SCORE:
0.6696
HELIX:
0.0205
FCONS_SCORE:
0.8751
RIG_SCORE:
0.5573
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G279S
DO224613
LUSC
ICGC
IPPTPSTS
DEG_SCF_FBW7_1
0.0833
p.P265S
ACH-000088
Non-Cancerous
CCLE
IPPTPSTS
DEG_SCF_FBW7_1
0.5641
Drug responses associated with AGAP9 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IPPTPSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5VTM2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9
DEG_SCF_FBW7_1
263:270
IPPTPSTS
FBXW7
0.9858
More...