DegronMD

Uniprot ID: Q9NZV8

Source protein: Potassium voltage-gated channel subfamily D member 2

Source gene: KCND2

Class: DEG_SCF_FBW7_1

Location: 600:606

E3 ligase: FBXW7

DEGRON score: 0.9964

ASA_SCORE: 76.9571

COIL: 0.9011

CONS_SCORE: 0.3419

DSS_SCORE: 0.61

HELIX: 0.0081

FCONS_SCORE: 1.0097

RIG_SCORE: 0.7065

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D612N	TCGA-EE-A2GS	SKCM	TCGA	IPTPPVT	DEG_SCF_FBW7_1	0.1667
p.D612N	TCGA-JW-A5VL	CESC	TCGA	IPTPPVT	DEG_SCF_FBW7_1	0.1667
p.D612N	TCGA-V5-AASV	ESCA	TCGA	IPTPPVT	DEG_SCF_FBW7_1	0.1667
p.D612N	DO49976	CESC	ICGC	IPTPPVT	DEG_SCF_FBW7_1	0.1667
p.D612N	DO222880	MELA	ICGC	IPTPPVT	DEG_SCF_FBW7_1	0.1667
p.D612N	DO37465	SKCM	ICGC	IPTPPVT	DEG_SCF_FBW7_1	0.1667
p.P601Q	TCGA-ER-A2NF	SKCM	TCGA	IPTPPVT	DEG_SCF_FBW7_1	0.5924
p.P601Q	DO47451	SKCM	ICGC	IPTPPVT	DEG_SCF_FBW7_1	0.5924
p.E615K	TCGA-OD-A75X	SKCM	TCGA	IPTPPVT	DEG_SCF_FBW7_1	0.0833
p.E615K	DO48601	SKCM	ICGC	IPTPPVT	DEG_SCF_FBW7_1	0.0833
p.P603L	DO222884	COCA	ICGC	IPTPPVT	DEG_SCF_FBW7_1	0.7582
p.T606I	DO50450	ESAD	ICGC	IPTPPVT	DEG_SCF_FBW7_1	0.7078
p.D612Y	DO229027	LICA	ICGC	IPTPPVT	DEG_SCF_FBW7_1	0.1667
p.P601T	DO220891	MELA	ICGC	IPTPPVT	DEG_SCF_FBW7_1	0.5919
p.Q590P	SIDM01582	Gastric Carcinoma	GDSC	IPTPPVT	DEG_SCF_FBW7_1	0.0556
p.Q590P	ACH-000507	Gastric Cancer	CCLE	IPTPPVT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZV8	Potassium voltage-gated channel subfamily D member 2	DEG_SCF_FBW7_1	600:606	IPTPPVT	FBXW7	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons