DegronMD

Uniprot ID: Q8N1N0

Source protein: C-type lectin domain family 4 member F

Source gene: CLEC4F

Class: SCF_FBXL2

Location: 317:326

E3 ligase: FBXL2

DEGRON score: 0.7662

ASA_SCORE: 100.33

COIL: 0.0878

CONS_SCORE: 0.6713

DSS_SCORE: 0.3119

HELIX: 0.9142

FCONS_SCORE: 1.0611

RIG_SCORE: 0.79

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E330D	TCGA-05-5425	LUAD	TCGA	IQFLRGHLER	SCF_FBXL2	0.2222
p.E330D	DO26270	LUAD	ICGC	IQFLRGHLER	SCF_FBXL2	0.2222
p.N312S	TCGA-F4-6809	COAD	TCGA	IQFLRGHLER	SCF_FBXL2	0.1944
p.N312S	DO10164	COAD	ICGC	IQFLRGHLER	SCF_FBXL2	0.1944
p.A315T	TCGA-F7-A624	HNSC	TCGA	IQFLRGHLER	SCF_FBXL2	0.2778
p.A315T	DO44440	HNSC	ICGC	IQFLRGHLER	SCF_FBXL2	0.2778
p.H332Y	TCGA-FR-A7U9	SKCM	TCGA	IQFLRGHLER	SCF_FBXL2	0.1667
p.H332Y	DO48546	SKCM	ICGC	IQFLRGHLER	SCF_FBXL2	0.1667
p.H332Y	SIDM01175	Other Sarcomas	GDSC	IQFLRGHLER	SCF_FBXL2	0.1667
p.H332Y	SIDM00063	Melanoma	GDSC	IQFLRGHLER	SCF_FBXL2	0.1667
p.H332Y	ACH-002309	Sarcoma	CCLE	IQFLRGHLER	SCF_FBXL2	0.1667
p.H332Y	SW684	soft_tissue	COSMIC	IQFLRGHLER	SCF_FBXL2	0.1667
p.E330K	TCGA-HE-7130	KIRP	TCGA	IQFLRGHLER	SCF_FBXL2	0.2222
p.E330K	DO20776	KIRP	ICGC	IQFLRGHLER	SCF_FBXL2	0.2222
p.E330K	DO222749	MELA	ICGC	IQFLRGHLER	SCF_FBXL2	0.2222
p.R321S	DO48581	PAEN	ICGC	IQFLRGHLER	SCF_FBXL2	0.7427
p.E316D	ACH-001991	Primary	CCLE	IQFLRGHLER	SCF_FBXL2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1N0	C-type lectin domain family 4 member F	SCF_FBXL2	317:326	IQFLRGHLER	FBXL2	0.7662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons