DegronMD

Uniprot ID: Q86X52

Source protein: Chondroitin sulfate synthase 1

Source gene: CHSY1

Class: LIG_APCC_ABBA_1

Location: 332:337

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8771

ASA_SCORE: 82.9667

COIL: 0.3455

CONS_SCORE: 0.576

DSS_SCORE: 0.1852

HELIX: 0.6005

FCONS_SCORE: 1.3322

RIG_SCORE: 0.8485

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V339F	TCGA-55-7994	LUAD	TCGA	IQLHRE	LIG_APCC_ABBA_1	0.2778
p.V339F	DO45311	LUAD	ICGC	IQLHRE	LIG_APCC_ABBA_1	0.2778
p.I332T	TCGA-BR-6452	STAD	TCGA	IQLHRE	LIG_APCC_ABBA_1	0.7078
p.I332T	DO38404	STAD	ICGC	IQLHRE	LIG_APCC_ABBA_1	0.7078
p.E326K	TCGA-CM-4746	COAD	TCGA	IQLHRE	LIG_APCC_ABBA_1	0.1667
p.E326K	TCGA-EO-A22X	UCEC	TCGA	IQLHRE	LIG_APCC_ABBA_1	0.1667
p.E326K	DO7882	COAD	ICGC	IQLHRE	LIG_APCC_ABBA_1	0.1667
p.E326K	DO43907	UCEC	ICGC	IQLHRE	LIG_APCC_ABBA_1	0.1667
p.R336S	TCGA-D3-A2J6	SKCM	TCGA	IQLHRE	LIG_APCC_ABBA_1	0.6316
p.R336S	DO37901	SKCM	ICGC	IQLHRE	LIG_APCC_ABBA_1	0.6316
p.R322C	TCGA-EE-A29C	SKCM	TCGA	IQLHRE	LIG_APCC_ABBA_1	0.0556
p.R322C	DO222727	MELA	ICGC	IQLHRE	LIG_APCC_ABBA_1	0.0556
p.R322C	DO38028	SKCM	ICGC	IQLHRE	LIG_APCC_ABBA_1	0.0556
p.R322C	SIDM00429	B-Lymphoblastic Leukemia	GDSC	IQLHRE	LIG_APCC_ABBA_1	0.0556
p.R322C	ACH-000938	Leukemia	CCLE	IQLHRE	LIG_APCC_ABBA_1	0.0556
p.R322C	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	IQLHRE	LIG_APCC_ABBA_1	0.0556
p.R336C	TCGA-K1-A6RT	SARC	TCGA	IQLHRE	LIG_APCC_ABBA_1	0.719
p.R336C	DO220193	SARC	ICGC	IQLHRE	LIG_APCC_ABBA_1	0.719
p.H335N	DO229025	LICA	ICGC	IQLHRE	LIG_APCC_ABBA_1	0.7423
p.E337K	SIDM01611	Endometrial Carcinoma	GDSC	IQLHRE	LIG_APCC_ABBA_1	0.7022
p.E337K	ACH-000996	Endometrial/Uterine Cancer	CCLE	IQLHRE	LIG_APCC_ABBA_1	0.7022
p.R330C	ACH-000597	Rhabdoid	CCLE	IQLHRE	LIG_APCC_ABBA_1	0.2778
p.R330C	ACH-001200	Rhabdoid	CCLE	IQLHRE	LIG_APCC_ABBA_1	0.2778
p.L327I	ACH-000918	Leukemia	CCLE	IQLHRE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86X52	Chondroitin sulfate synthase 1	LIG_APCC_ABBA_1	332:337	IQLHRE	APC,CDC20,FZR1	0.8771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons