DegronMD

Uniprot ID: P25208

Source protein: Nuclear transcription factor Y subunit beta

Source gene: NFYB

Class: LIG_APCC_ABBA_1

Location: 29:34

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9648

ASA_SCORE: 109.4833

COIL: 0.939

CONS_SCORE: 0.5548

DSS_SCORE: 0.6557

HELIX: 0.0177

FCONS_SCORE: 0.9862

RIG_SCORE: 0.6928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M39T	TCGA-AZ-6598	COAD	TCGA	IQPHDD	LIG_APCC_ABBA_1	0.1944
p.M39T	DO10276	COAD	ICGC	IQPHDD	LIG_APCC_ABBA_1	0.1944
p.H42R	TCGA-D1-A17Q	UCEC	TCGA	IQPHDD	LIG_APCC_ABBA_1	0.1111
p.H42R	DO41903	UCEC	ICGC	IQPHDD	LIG_APCC_ABBA_1	0.1111
p.I29V	DO50367	ESAD	ICGC	IQPHDD	LIG_APCC_ABBA_1	0.5965
p.S38R	DO229037	LICA	ICGC	IQPHDD	LIG_APCC_ABBA_1	0.2222
p.D37G	DO228138	PBCA	ICGC	IQPHDD	LIG_APCC_ABBA_1	0.25
p.S38N	SIDM00447	B-Lymphoblastic Leukemia	GDSC	IQPHDD	LIG_APCC_ABBA_1	0.2222
p.S38N	ACH-000960	Leukemia	CCLE	IQPHDD	LIG_APCC_ABBA_1	0.2222
p.S38N	REH	haematopoietic_and_lymphoid_tissue	COSMIC	IQPHDD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25208	Nuclear transcription factor Y subunit beta	LIG_APCC_ABBA_1	29:34	IQPHDD	APC,CDC20,FZR1	0.9648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons