DegronMD

Uniprot ID: Q15776

Source protein: Zinc finger protein with KRAB and SCAN domains 8

Source gene: ZKSCAN8

Class: LIG_APCC_ABBA_1

Location: 279:284

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8911

ASA_SCORE: 71.6833

COIL: 0.6922

CONS_SCORE: 0.8613

DSS_SCORE: 0.5204

HELIX: 0.1918

FCONS_SCORE: 1.1176

RIG_SCORE: 0.6668

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E284V	TCGA-56-7222	LUSC	TCGA	IQPHGE	LIG_APCC_ABBA_1	0.7693
p.E284V	DO26842	LUSC	ICGC	IQPHGE	LIG_APCC_ABBA_1	0.7693
p.T277A	TCGA-6A-AB49	LUSC	TCGA	IQPHGE	LIG_APCC_ABBA_1	0.2778
p.T277A	DO52020	LUSC	ICGC	IQPHGE	LIG_APCC_ABBA_1	0.2778
p.S276Y	TCGA-B5-A11N	UCEC	TCGA	IQPHGE	LIG_APCC_ABBA_1	0.25
p.S276Y	DO41458	UCEC	ICGC	IQPHGE	LIG_APCC_ABBA_1	0.25
p.Q280L	TCGA-BH-A18J	BRCA	TCGA	IQPHGE	LIG_APCC_ABBA_1	0.6654
p.Q280L	DO4527	BRCA	ICGC	IQPHGE	LIG_APCC_ABBA_1	0.6654
p.G278E	DO234292	ESAD	ICGC	IQPHGE	LIG_APCC_ABBA_1	0.3056
p.N290Y	SIDM00132	Pancreatic Carcinoma	GDSC	IQPHGE	LIG_APCC_ABBA_1	0.1667
p.N290Y	ACH-000535	Pancreatic Cancer	CCLE	IQPHGE	LIG_APCC_ABBA_1	0.1667
p.N290Y	BxPC-3	pancreas	COSMIC	IQPHGE	LIG_APCC_ABBA_1	0.1667
p.G283V	ACH-001687	Kidney Cancer	CCLE	IQPHGE	LIG_APCC_ABBA_1	0.6421

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15776	Zinc finger protein with KRAB and SCAN domains 8	LIG_APCC_ABBA_1	279:284	IQPHGE	APC,CDC20,FZR1	0.8911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons