DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
IQRGPVR
Uniprot ID:
P08708
Source protein:
40S ribosomal protein S17
Source gene:
RPS17
Class:
SCF_FBXL2
Location:
61:67
E3 ligase:
FBXL2
DEGRON score:
0.888
ASA_SCORE:
104.5286
COIL:
0.7537
CONS_SCORE:
0.8698
DSS_SCORE:
0.2794
HELIX:
0.1087
FCONS_SCORE:
0.9765
RIG_SCORE:
0.7523
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R67K
SIDM01519
Head and Neck Carcinoma
GDSC
IQRGPVR
SCF_FBXL2
0.7237
Drug responses associated with RPS17 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IQRGPVR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P08708
40S ribosomal protein S17
SCF_FBXL2
61:67
IQRGPVR
FBXL2
0.888
More...
