DegronMD

Uniprot ID: Q8NEV4

Source protein: Myosin-IIIa

Source gene: MYO3A

Class: SCF_FBXL2

Location: 1353:1363

E3 ligase: FBXL2

DEGRON score: 0.8385

ASA_SCORE: 106.6636

COIL: 0.4517

CONS_SCORE: 0.4095

DSS_SCORE: 0.4409

HELIX: 0.5366

FCONS_SCORE: 1.1665

RIG_SCORE: 0.798

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1345K	TCGA-29-1776	OV	TCGA	IQSKYRGYKRR	SCF_FBXL2	0.1111
p.E1345K	DO30810	OV	ICGC	IQSKYRGYKRR	SCF_FBXL2	0.1111
p.A1350V	TCGA-AX-A3G8	UCEC	TCGA	IQSKYRGYKRR	SCF_FBXL2	0.25
p.A1350V	DO41014	UCEC	ICGC	IQSKYRGYKRR	SCF_FBXL2	0.25
p.K1370N	TCGA-AZ-4315	COAD	TCGA	IQSKYRGYKRR	SCF_FBXL2	0.25
p.K1370N	DO8842	COAD	ICGC	IQSKYRGYKRR	SCF_FBXL2	0.25
p.A1349E	TCGA-CR-7382	HNSC	TCGA	IQSKYRGYKRR	SCF_FBXL2	0.2222
p.A1349E	DO14171	HNSC	ICGC	IQSKYRGYKRR	SCF_FBXL2	0.2222
p.D1369N	TCGA-DU-6407	LGG	TCGA	IQSKYRGYKRR	SCF_FBXL2	0.1667
p.D1369N	DO22295	LGG	ICGC	IQSKYRGYKRR	SCF_FBXL2	0.1667
p.S1372Y	TCGA-F5-6814	READ	TCGA	IQSKYRGYKRR	SCF_FBXL2	0.0833
p.S1372Y	DO36556	READ	ICGC	IQSKYRGYKRR	SCF_FBXL2	0.0833
p.Q1365H	TCGA-HT-7688	LGG	TCGA	IQSKYRGYKRR	SCF_FBXL2	0.2778
p.Q1365H	DO22403	LGG	ICGC	IQSKYRGYKRR	SCF_FBXL2	0.2778
p.D1347H	TCGA-K4-A83P	BLCA	TCGA	IQSKYRGYKRR	SCF_FBXL2	0.1667
p.D1347H	DO49787	BLCA	ICGC	IQSKYRGYKRR	SCF_FBXL2	0.1667
p.K1368E	DO220823	BRCA	ICGC	IQSKYRGYKRR	SCF_FBXL2	0.3056
p.G1359C	DO229019	LICA	ICGC	IQSKYRGYKRR	SCF_FBXL2	0.76
p.R1363S	DO229036	LICA	ICGC	IQSKYRGYKRR	SCF_FBXL2	0.6316
p.G1359S	DO229054	LICA	ICGC	IQSKYRGYKRR	SCF_FBXL2	0.6993
p.S1355G	DO220916	WT	ICGC	IQSKYRGYKRR	SCF_FBXL2	0.6993
p.Q1343H	SIDM00789	Colorectal Carcinoma	GDSC	IQSKYRGYKRR	SCF_FBXL2	0.0556
p.Q1343H	ACH-000997	Colon/Colorectal Cancer	CCLE	IQSKYRGYKRR	SCF_FBXL2	0.0556
p.Q1343H	HCT-15	large_intestine	COSMIC	IQSKYRGYKRR	SCF_FBXL2	0.0556
p.Y1357N	SIDM00238	Ovarian Carcinoma	GDSC	IQSKYRGYKRR	SCF_FBXL2	0.5948
p.Y1357N	ACH-000947	Ovarian Cancer	CCLE	IQSKYRGYKRR	SCF_FBXL2	0.5948
p.Y1357N	OVK-18	ovary	COSMIC	IQSKYRGYKRR	SCF_FBXL2	0.5948
p.V1351I	ACH-000568	Breast Cancer	CCLE	IQSKYRGYKRR	SCF_FBXL2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEV4	Myosin-IIIa	SCF_FBXL2	1353:1363	IQSKYRGYKRR	FBXL2	0.8385	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IQSKYRGYKRR

Degron related mutations and impact score

Drug responses associated with MYO3A mutations

All proteins holding degron of IQSKYRGYKRR