DegronMD

Uniprot ID: P53992

Source protein: Protein transport protein Sec24C

Source gene: SEC24C

Class: DEG_SCF_FBW7_1

Location: 199:205

E3 ligase: FBXW7

DEGRON score: 0.9954

ASA_SCORE: 100.7286

COIL: 0.9637

CONS_SCORE: 0.2891

DSS_SCORE: 0.8423

HELIX: 0.0149

FCONS_SCORE: 1.1597

RIG_SCORE: 0.5928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P202T	TCGA-21-1079	LUSC	TCGA	IQTPQRS	DEG_SCF_FBW7_1	0.7031
p.A210S	TCGA-50-5930	LUAD	TCGA	IQTPQRS	DEG_SCF_FBW7_1	0.1944
p.S205F	TCGA-A8-A08H	BRCA	TCGA	IQTPQRS	DEG_SCF_FBW7_1	0.7982
p.P197H	TCGA-B5-A1MX	UCEC	TCGA	IQTPQRS	DEG_SCF_FBW7_1	0.2778
p.H196Y	TCGA-CK-4951	COAD	TCGA	IQTPQRS	DEG_SCF_FBW7_1	0.25
p.Q194R	TCGA-D3-A8GK	SKCM	TCGA	IQTPQRS	DEG_SCF_FBW7_1	0.1944
p.P197S	DO224955	BRCA	ICGC	IQTPQRS	DEG_SCF_FBW7_1	0.2778
p.P193H	DO233284	GACA	ICGC	IQTPQRS	DEG_SCF_FBW7_1	0.1667
p.V207I	DO233628	GACA	ICGC	IQTPQRS	DEG_SCF_FBW7_1	0.2778
p.K207R	DO233871	GACA	ICGC	IQTPQRS	DEG_SCF_FBW7_1	0.2778
p.G196W	DO228974	LICA	ICGC	IQTPQRS	DEG_SCF_FBW7_1	0.25
p.M210I	DO228986	LICA	ICGC	IQTPQRS	DEG_SCF_FBW7_1	0.1944
p.C203F	DO229038	LICA	ICGC	IQTPQRS	DEG_SCF_FBW7_1	0.7108
p.P206S	DO219379	PRAD	ICGC	IQTPQRS	DEG_SCF_FBW7_1	0.3056
p.T191I	DO37474	SKCM	ICGC	IQTPQRS	DEG_SCF_FBW7_1	0.1111
p.E197D	DO40884	UCEC	ICGC	IQTPQRS	DEG_SCF_FBW7_1	0.2778
p.R202C	DO40996	UCEC	ICGC	IQTPQRS	DEG_SCF_FBW7_1	0.8301
p.G198V	SIDM00438	B-Lymphoblastic Leukemia	GDSC	IQTPQRS	DEG_SCF_FBW7_1	0.3056
p.G198V	ACH-002275	Leukemia	CCLE	IQTPQRS	DEG_SCF_FBW7_1	0.3056
p.G198V	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	IQTPQRS	DEG_SCF_FBW7_1	0.3056
p.A206S	ACH-001280	Sarcoma	CCLE	IQTPQRS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53992	Protein transport protein Sec24C	DEG_SCF_FBW7_1	199:205	IQTPQRS	FBXW7	0.9954	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons