DegronMD

Uniprot ID: O95786

Source protein: Antiviral innate immune response receptor RIG-I

Source gene: DDX58

Class: SCF_FBXL2

Location: 725:734

E3 ligase: FBXL2

DEGRON score: 0.7892

ASA_SCORE: 78.85

COIL: 0.493

CONS_SCORE: 0.7684

DSS_SCORE: 0.1781

HELIX: 0.2959

FCONS_SCORE: 1.2899

RIG_SCORE: 0.8062

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R730T	TCGA-AZ-6605	COAD	TCGA	IQTRGRGRAR	SCF_FBXL2	0.6765
p.S736R	TCGA-WK-A8XO	SARC	TCGA	IQTRGRGRAR	SCF_FBXL2	0.2778
p.H741Y	DO1262	BRCA	ICGC	IQTRGRGRAR	SCF_FBXL2	0.1389
p.A729S	DO51407	PRAD	ICGC	IQTRGRGRAR	SCF_FBXL2	0.7588
p.Q739K	DO229245	THCA	ICGC	IQTRGRGRAR	SCF_FBXL2	0.1944
p.D718Y	DO40884	UCEC	ICGC	IQTRGRGRAR	SCF_FBXL2	0.1389
p.E742K	DO42793	UCEC	ICGC	IQTRGRGRAR	SCF_FBXL2	0.1111
p.K743T	DO43971	UCEC	ICGC	IQTRGRGRAR	SCF_FBXL2	0.0833
p.M715I	DO43971	UCEC	ICGC	IQTRGRGRAR	SCF_FBXL2	0.0556
p.N744D	SIDM00449	B-Lymphoblastic Leukemia	GDSC	IQTRGRGRAR	SCF_FBXL2	0.0556
p.N744D	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	IQTRGRGRAR	SCF_FBXL2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95786	Antiviral innate immune response receptor RIG-I	SCF_FBXL2	725:734	IQTRGRGRAR	FBXL2	0.7892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons