DegronMD

Uniprot ID: Q92841

Source protein: Probable ATP-dependent RNA helicase DDX17

Source gene: DDX17

Class: DEG_APCC_DBOX_1

Location: 67:75

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9976

ASA_SCORE: 68.7444

COIL: 0.8643

CONS_SCORE: 0.2399

DSS_SCORE: 0.537

HELIX: 0.0822

FCONS_SCORE: -0.0013

RIG_SCORE: 0.7298

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P59Q	TCGA-AX-A2HC	UCEC	TCGA	IRAPLPDLY	DEG_APCC_DBOX_1	0.1111
p.P59Q	DO41572	UCEC	ICGC	IRAPLPDLY	DEG_APCC_DBOX_1	0.1111
p.P63Q	TCGA-FE-A23A	THCA	TCGA	IRAPLPDLY	DEG_APCC_DBOX_1	0.2222
p.P63Q	DO38970	THCA	ICGC	IRAPLPDLY	DEG_APCC_DBOX_1	0.2222
p.G72E	DO51612	CESC	ICGC	IRAPLPDLY	DEG_APCC_DBOX_1	0.7199
p.E59K	DO51612	CESC	ICGC	IRAPLPDLY	DEG_APCC_DBOX_1	0.1111
p.P60L	DO51734	COAD	ICGC	IRAPLPDLY	DEG_APCC_DBOX_1	0.1389
p.G68D	DO7798	COAD	ICGC	IRAPLPDLY	DEG_APCC_DBOX_1	0.7198
p.E78G	DO227990	COCA	ICGC	IRAPLPDLY	DEG_APCC_DBOX_1	0.25
p.R75Q	DO10880	GBM	ICGC	IRAPLPDLY	DEG_APCC_DBOX_1	0.7329
p.T79N	DO228974	LICA	ICGC	IRAPLPDLY	DEG_APCC_DBOX_1	0.6667
p.R57P	DO52305	LIHC	ICGC	IRAPLPDLY	DEG_APCC_DBOX_1	0.0556
p.P76L	DO220885	MELA	ICGC	IRAPLPDLY	DEG_APCC_DBOX_1	0.3056
p.R82S	DO27983	OV	ICGC	IRAPLPDLY	DEG_APCC_DBOX_1	0.1389
p.S76Y	DO37921	SKCM	ICGC	IRAPLPDLY	DEG_APCC_DBOX_1	0.3056
p.G70V	DO229253	THCA	ICGC	IRAPLPDLY	DEG_APCC_DBOX_1	0.7532
p.R82G	DO52412	UCEC	ICGC	IRAPLPDLY	DEG_APCC_DBOX_1	0.1389
p.Y75C	SIDM00473	Oral Cavity Carcinoma	GDSC	IRAPLPDLY	DEG_APCC_DBOX_1	0.7087
p.Y75C	ACH-000619	Head and Neck Cancer	CCLE	IRAPLPDLY	DEG_APCC_DBOX_1	0.7087
p.P59L	SIDM00489	Oral Cavity Carcinoma	GDSC	IRAPLPDLY	DEG_APCC_DBOX_1	0.1111
p.P59L	SIDM00289	B-Lymphoblastic Leukemia	GDSC	IRAPLPDLY	DEG_APCC_DBOX_1	0.1111
p.P59L	SIDM00316	Glioblastoma	GDSC	IRAPLPDLY	DEG_APCC_DBOX_1	0.1111
p.P59L	SIDM01435	Hepatocellular Carcinoma	GDSC	IRAPLPDLY	DEG_APCC_DBOX_1	0.1111
p.P59L	SIDM01450	Gastric Carcinoma	GDSC	IRAPLPDLY	DEG_APCC_DBOX_1	0.1111
p.P59L	SIDM00162	Biliary Tract Carcinoma	GDSC	IRAPLPDLY	DEG_APCC_DBOX_1	0.1111
p.L62F	ACH-000938	Leukemia	CCLE	IRAPLPDLY	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92841	Probable ATP-dependent RNA helicase DDX17	DEG_APCC_DBOX_1	67:75	IRAPLPDLY	APC,CDC20,FZR1	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRAPLPDLY

Degron related mutations and impact score

Drug responses associated with DDX17 mutations

All proteins holding degron of IRAPLPDLY