DegronMD

Uniprot ID: Q9BY31

Source protein: Zinc finger protein 717

Source gene: ZNF717

Class: DEG_SCF_SKP2-CKS1_1

Location: 693:700

E3 ligase: SKP2,CSK1

DEGRON score: 0.6995

ASA_SCORE: 76.95

COIL: 0.6754

CONS_SCORE: 0.2172

DSS_SCORE: 0.2446

HELIX: 0.0964

FCONS_SCORE: 0.6486

RIG_SCORE: 0.7992

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E695K	TCGA-EY-A1GI	UCEC	TCGA	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.H699Y	DO51730	COAD	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.7229
p.H702Q	DO224655	COCA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.H702Q	DO224668	COCA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.H702Q	DO224739	COCA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.H702Q	DO222571	COCA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.H702Q	DO222822	COCA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.H702Q	DO229250	THCA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.Y708F	DO224655	COCA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.Y708F	DO224668	COCA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.Y708F	DO224739	COCA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.Y708F	DO222755	COCA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.Y708F	DO222709	COCA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.Y708F	DO222822	COCA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.C690G	DO222568	COCA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	DO229489	LAML	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	DO228947	LICA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00437	Acute Myeloid Leukemia	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00958	Chronic Myelogenous Leukemia	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM01034	B-Lymphoblastic Leukemia	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00565	Oral Cavity Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM01005	Acute Myeloid Leukemia	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00394	Cervical Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00492	Glioblastoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM01093	Cervical Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00687	Gastric Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00360	Other Solid Cancers	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00375	Head and Neck Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00564	Ovarian Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00498	Colorectal Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00247	Gastric Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM01265	Plasma Cell Myeloma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00618	Hepatocellular Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM01217	Other Blood Cancers	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00566	Oral Cavity Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00289	B-Lymphoblastic Leukemia	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00316	Glioblastoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00604	Oral Cavity Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM01018	Hodgkin's Lymphoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00273	Glioblastoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM01728	Endometrial Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM01582	Gastric Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM00165	Other Solid Cancers	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM01368	Gastric Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM01781	Gastric Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM01336	Glioblastoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM01469	Pancreatic Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.C690G	SIDM01494	Glioblastoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.E709K	DO229016	COCA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.0833
p.T703N	DO229016	COCA	ICGC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.A684V	SIDM01196	Hepatocellular Carcinoma	GDSC	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.0833
p.V697A	ACH-000990	Endometrial/Uterine Cancer	CCLE	IRELTPGK	DEG_SCF_SKP2-CKS1_1	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRELTPGK

Degron related mutations and impact score

Drug responses associated with ZNF717 mutations

All proteins holding degron of IRELTPGK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BY31	Zinc finger protein 717	DEG_SCF_SKP2-CKS1_1	693:700	IRELTPGK	SKP2,CSK1	0.6995	More...