DegronMD

Uniprot ID: P02649

Source protein: Apolipoprotein E

Source gene: APOE

Class: DEG_APCC_DBOX_1

Location: 195:203

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7019

ASA_SCORE: 75.2

COIL: 0.2603

CONS_SCORE: 0.6119

DSS_SCORE: 0.3418

HELIX: 0.7371

FCONS_SCORE: 1.2313

RIG_SCORE: 0.7586

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R185S	TCGA-DA-A1I1	SKCM	TCGA	IRERLGPLV	DEG_APCC_DBOX_1	0.0556
p.R185S	DO37966	SKCM	ICGC	IRERLGPLV	DEG_APCC_DBOX_1	0.0556
p.R196C	DO234262	ESAD	ICGC	IRERLGPLV	DEG_APCC_DBOX_1	0.8301
p.A194T	DO228510	PRAD	ICGC	IRERLGPLV	DEG_APCC_DBOX_1	0.3056
p.R207H	SIDM00216	Colorectal Carcinoma	GDSC	IRERLGPLV	DEG_APCC_DBOX_1	0.2222
p.G191D	SIDM00951	T-Lymphoblastic Leukemia	GDSC	IRERLGPLV	DEG_APCC_DBOX_1	0.2222
p.G191D	ACH-001737	Leukemia	CCLE	IRERLGPLV	DEG_APCC_DBOX_1	0.2222
p.A211T	ACH-000856	Breast Cancer	CCLE	IRERLGPLV	DEG_APCC_DBOX_1	0.1111
p.A211T	ACH-000955	Colon/Colorectal Cancer	CCLE	IRERLGPLV	DEG_APCC_DBOX_1	0.1111
p.R198H	ACH-000967	Colon/Colorectal Cancer	CCLE	IRERLGPLV	DEG_APCC_DBOX_1	0.7133
p.G191C	ACH-000987	Skin Cancer	CCLE	IRERLGPLV	DEG_APCC_DBOX_1	0.2222
p.V208M	ACH-001518	Endometrial/Uterine Cancer	CCLE	IRERLGPLV	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02649	Apolipoprotein E	DEG_APCC_DBOX_1	195:203	IRERLGPLV	APC,CDC20,FZR1	0.7019	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons