DegronMD

Uniprot ID: P07942

Source protein: Laminin subunit beta-1

Source gene: LAMB1

Class: DEG_APCC_DBOX_1

Location: 1314:1322

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.515

ASA_SCORE: 50.3111

COIL: 0.1013

CONS_SCORE: 0.445

DSS_SCORE: 0.2034

HELIX: 0.8931

FCONS_SCORE: 1.2256

RIG_SCORE: 0.7979

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1315W	TCGA-AP-A1DV	UCEC	TCGA	IRGALDSIT	DEG_APCC_DBOX_1	0.8634
p.R1315W	TCGA-C5-A1MQ	CESC	TCGA	IRGALDSIT	DEG_APCC_DBOX_1	0.8634
p.T1322A	TCGA-B0-5098	KIRC	TCGA	IRGALDSIT	DEG_APCC_DBOX_1	0.6028
p.E1332K	TCGA-CA-6718	COAD	TCGA	IRGALDSIT	DEG_APCC_DBOX_1	0.0556
p.D1319A	TCGA-DF-A2KN	UCEC	TCGA	IRGALDSIT	DEG_APCC_DBOX_1	0.6682
p.A1331T	TCGA-EE-A2MS	SKCM	TCGA	IRGALDSIT	DEG_APCC_DBOX_1	0.0833
p.K1310E	TCGA-JW-A5VG	CESC	TCGA	IRGALDSIT	DEG_APCC_DBOX_1	0.6667
p.A1327D	DO224751	BRCA	ICGC	IRGALDSIT	DEG_APCC_DBOX_1	0.1944
p.S1311F	DO3904	BRCA	ICGC	IRGALDSIT	DEG_APCC_DBOX_1	0.25
p.S1311F	DO229465	SKCA	ICGC	IRGALDSIT	DEG_APCC_DBOX_1	0.25
p.T1305K	DO228948	LICA	ICGC	IRGALDSIT	DEG_APCC_DBOX_1	0.0833
p.A1316D	DO229025	LICA	ICGC	IRGALDSIT	DEG_APCC_DBOX_1	0.7793
p.Q1313K	DO229026	LICA	ICGC	IRGALDSIT	DEG_APCC_DBOX_1	0.3056
p.Q1313K	DO229045	LICA	ICGC	IRGALDSIT	DEG_APCC_DBOX_1	0.3056
p.A1306T	DO38332	STAD	ICGC	IRGALDSIT	DEG_APCC_DBOX_1	0.1111
p.M1327I	SIDM00720	Mesothelioma	GDSC	IRGALDSIT	DEG_APCC_DBOX_1	0.1944
p.M1327I	ACH-000648	Lung Cancer	CCLE	IRGALDSIT	DEG_APCC_DBOX_1	0.1944
p.M1327I	NCI-H28	pleura	COSMIC	IRGALDSIT	DEG_APCC_DBOX_1	0.1944
p.K1310T	SIDM01611	Endometrial Carcinoma	GDSC	IRGALDSIT	DEG_APCC_DBOX_1	0.6667
p.K1310T	ACH-000996	Endometrial/Uterine Cancer	CCLE	IRGALDSIT	DEG_APCC_DBOX_1	0.6667
p.I1321T	ACH-000961	Endometrial/Uterine Cancer	CCLE	IRGALDSIT	DEG_APCC_DBOX_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07942	Laminin subunit beta-1	DEG_APCC_DBOX_1	1314:1322	IRGALDSIT	APC,CDC20,FZR1	0.515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons