DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IRIFPE
Uniprot ID:
Q8IXT1
Source protein:
DNA damage-induced apoptosis suppressor protein
Source gene:
DDIAS
Class:
LIG_APCC_ABBA_1
Location:
808:813
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8178
ASA_SCORE:
95.7333
COIL:
0.7043
CONS_SCORE:
0.4458
DSS_SCORE:
0.506
HELIX:
0.1263
FCONS_SCORE:
1.0021
RIG_SCORE:
0.8164
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DDIAS mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IRIFPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IXT1
DNA damage-induced apoptosis suppressor protein
LIG_APCC_ABBA_1
808:813
IRIFPE
APC,CDC20,FZR1
0.8178
More...