DegronMD

Uniprot ID: Q9UN75

Source protein: Protocadherin alpha-12

Source gene: PCDHA12

Class: LIG_APCC_ABBA_1

Location: 302:307

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8544

ASA_SCORE: 66.6333

COIL: 0.122

CONS_SCORE: 0.4857

DSS_SCORE: 0.2762

HELIX: 0.0033

FCONS_SCORE: 0.8209

RIG_SCORE: 0.8795

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I302L	TCGA-B5-A3FA	UCEC	TCGA	IRIYGE	LIG_APCC_ABBA_1	0.6063
p.I302L	DO52402	UCEC	ICGC	IRIYGE	LIG_APCC_ABBA_1	0.6063
p.E312K	TCGA-EB-A82B	SKCM	TCGA	IRIYGE	LIG_APCC_ABBA_1	0.1944
p.E312K	TCGA-FR-A726	SKCM	TCGA	IRIYGE	LIG_APCC_ABBA_1	0.1944
p.E312K	TCGA-OD-A75X	SKCM	TCGA	IRIYGE	LIG_APCC_ABBA_1	0.1944
p.E312K	DO50294	SKCM	ICGC	IRIYGE	LIG_APCC_ABBA_1	0.1944
p.E312K	DO48665	SKCM	ICGC	IRIYGE	LIG_APCC_ABBA_1	0.1944
p.E312K	DO48601	SKCM	ICGC	IRIYGE	LIG_APCC_ABBA_1	0.1944
p.I304N	TCGA-EE-A20C	SKCM	TCGA	IRIYGE	LIG_APCC_ABBA_1	0.728
p.I304N	DO222775	MELA	ICGC	IRIYGE	LIG_APCC_ABBA_1	0.728
p.I304N	DO47665	SKCM	ICGC	IRIYGE	LIG_APCC_ABBA_1	0.728
p.D309N	DO220873	MELA	ICGC	IRIYGE	LIG_APCC_ABBA_1	0.2778
p.E311K	SIDM00842	Colorectal Carcinoma	GDSC	IRIYGE	LIG_APCC_ABBA_1	0.2222
p.E311K	ACH-000202	Colon/Colorectal Cancer	CCLE	IRIYGE	LIG_APCC_ABBA_1	0.2222
p.E311K	COLO-320-HSR	large_intestine	COSMIC	IRIYGE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UN75	Protocadherin alpha-12	LIG_APCC_ABBA_1	302:307	IRIYGE	APC,CDC20,FZR1	0.8544	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons